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Kimmelmann and colleagues demonstrate the importance of non-cell autonomous function in tumors. Non cell autonomous functions of autophagy is an emerging aspect in the field.
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Dagdas YF et al., eLife (2016), 5:e10856, DOI: 10.7554/eLife.10856.001
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Hafrén A et al., PNAS (2017) 114: E2026-E2035, doi: 10.1073/pnas.1610687114
Nolan TM et al., Developmental Cell (2017) 41: 33-46, doi: 10.1016/j.devcel.2017.03.013
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This article describes the use of iron oxide (IO) nanoparticles to modulate the autophagic effect based on the dispersity of the nanoparticles in culture media. The results demonstrated that autophagy can be modulated by nanoparticles through tuning their dispersity.
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This review show different autophagy modulation processes mediated by nanomaterials. And it is summarized the effects of nanomaterials on autophagic processes in cancer, also considering the therapeutic outcome of synergism between nanomaterials and autophagy to improve existing cancer therapies.
Kyle M et al., The Journal of Cell Biology (2016), 214 (1): 25. DOI: 10.1083/jcb.201511042
This publication describes photoactivatable, acidifying nanoparticles (paNPs) able to internalize into lysosomes and enhance lysosomal acidity and function while decreasing p62 and LC3-II levels, indicating rescue of autophagic flux upon acute lysosomal acidification. Furthermore, paNPs improve glucose-stimulated insulin secretion that is reduced under lipotoxicity in INS1 cells and mouse islets. These results establish a causative role for impaired lysosomal acidification in the deregulation of autophagy and β-cell function under lipotoxicity.
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This review shows the role of different kind of nanoparticles in apoptosis and autophagy regulation. The cell autophagy process can be induced by various forms of stress, such as interactions with various types of NPs. Thus, NPs are considered a novel class of autophagy inducers. A growing number of reports have confirmed that NPs can induce and modulate autophagy in different cells. According to the current literature, NPs induce autophagy in two ways: NP-mediated ROS-dependent autophagy and NP-mediated lysosome-dependent autophagy. Among these mechanisms, ROS-modulated autophagy is thought to play a key role in NP-induced autophagy.
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This work presents alfa-Al2O3 nanoparticles as novel and efficient carriers for the delivery of antigens to the autophagosome-related cross-presentation pathway in antigen-presenting cells. They are also capable of boosting the antitumour efficacy of tumour-derived autophagosomes that contain limited amounts of unknown tumour-specific antigens. The demonstrated prototype of a-Al2O3-based cancer therapeutic vaccine may lead to re-engineering of the present aluminium adjuvant for effective therapeutic vaccines that can treat cancers and chronic infections.
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Morel E et al., Annu Rev Pharmacol Toxicol (2017) 57: 375-398. PMID: 28061686 Impact Factor: 14.769
Lim JA et al., EMBO Mol Med (2017) 9(3): 353-370. PMID: 28130275 Impact Factor: 9.547
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Masclaux-Daubresse C et al., Current Opinion in Plant Biology (2017) 39: 8-17. doi: 10.1016/j.pbi.2017.05.001. PMID: 28528166 Impact Factor: 7.357
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