WG | Name | Surnames | Country | City | Institution | Charge | Research Line |
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WG3 | Agnieszka | Sirko | Poland | Warsaw | Institut Of Biochemistry and Biophysics Polish | MCT / WG3 VL | Abiotic stress, Starvation, Nutrient deficit, Protein-protein interactions, Molecular biology, Ubiquitination. |
WG5 | Alejandro | Lucia | Spain | Madrid | Laureate - Universidad Europea | Improved autophagy as a main biological mechanism mediating the health benefits of physical exercise. | |
WG1 | Aleksandra | Isakovic | Serbia | Belgrade | University of Belgrade | MC S | |
WG2/WG4 | Alexander | Pintzas | Greece | Athens | National Hellenic Research Foundation | “My research interests have been in the scientific areas of Biology of Cancer and Cell Death, towards exploitation of the interplay of proliferative with apoptotic/autophagic pathways for novel cancer therapeutics and their rational combinations”. | |
WG1 | Ali | Kosar | Turkey | Istanbul | Sabanci University | Effects of cavitation on autophagy, Flow stresses on autophagy, Bubble collapse effect. | |
WG1 | Alicia | Alonso | Spain | Bilbao | Universidad del País Vasco. CSIC | Phospholipases and sphingomyelinases, influence of the physical state of the membrane on their enzymatic activity; ceramides, diacylglycerols; GPI-lipids; membrane fusion; lipid polymorphism. | |
WG3 | Alisdair | Fernie | Germany | Golm | Max Planck Gesellschaft | Autophagy's role in plant metabolism. | |
WG2/WG4 | Ana Vanessa | Oliveira | Portugal | Oeiras | Instituto de Biologia Experimental e Tecnológica and Instituto de Tecnologia Química e Biológica (ITQB/UNL) | Focused on translational science mainly biochemistry, cellular and molecular biology and its application to the field of gene therapy, development of biopolymers and diabetes. Interested in developing new disease models, including yeast models to complement tests in mammalian cells and animal models involved in the development of new therapeutical strategies. | |
WG1 | Anders H. | Lund | Denmark | Copenhagen | University of Copenhagen | MC T | Unveiling fundamental biological mechanisms and understand how these become perturbed during diseases, most prominently cancer, with the ambition to contribute to the development of clinical tools. |
WG1/WG4 | Andrea | Ballabio | Italy | Pozzuoli | TIGEM | To develop tools, to modulate cellular clearance and to use them to cure human diseases, including LSDs and neurodegenerative diseases such as Huntington’s, Alzheimer’s and Parkinson’s. | |
WG4 | Andrea | Cossarizza | Italy | Modena | University of Modenaand Reggio Emilia | MC S / TC VL | Immunopathogenesis of HIV infection; Immunology of Aging; Immunological alterations in Multiple Sclerosis; role of mitochondria in cell death and survival. |
WG4 | Angelo | De Milito | Sweden | Stockholm | Kaolinska Institut | MC T | Identify the mechanisms mediating the role of autophagy in cancer cells adaptation to acidosis. Identify effective autophagy inhibitors active on cancer cells adapted to acidosis. |
WG3 | Anna | Wawrzyńska | Poland | Warsaw | Institute of Biochemistry and Biophysics | MC S | |
WG1/WG4 | Anne | Simonsen | Norway | Oslo | University of Oslo-Institut Of Basic Medical Science | MC T | 1) Autophagy receptors and adaptors in selective autophagy, 2) Phosphoinositide-binding proteins in autophagy and 3) their role in disease. |
WG4 | Annemarie | Meijer | Netherlands | Leiden | Leiden University Institut of Biologie | MC T | Role of autophagy in host defense against intracellular bacteial infections. Using zebrafish as a model to study autophagy in vivo and recently found that the autophagy modulator dram1 is induced by Toll-like receptor and NFkB mediated signaling and protects the zebrafish host against mycobacterial infection. Using the zebrafish model for screening of autophagy-modulating drugs. |
WG3 | Antia | Rodriguez-Villalon | Switzerland | Zurich | ETH-Zurich | Vascular development study in which autophagy has a key role, in particupar in "postmortem" stages. | |
WG1/WG2/WG4 | Antonio | Zorzano | Spain | Barcelona | IRB Barcelona IRB Barcelona, University of Barcelona, CIBERDEM | Identification of novel modulators of autophagy and impact in complex metabolic diseases. | |
WG2/WG4 | Antonio | Cuadrado | Spain | Madrid | Universidad Autónoma de Madrid | Proteostasis alterations of Alzheimer and Parkinson’s disease and the possibility to use autophagy as a therapeutic target. | |
WG4/WG5 | Arnaud | Moris | France | Paris | Center for Immunology and Microbial infections - Paris | Host-Pathogen interactions, Adaptive Immunity, Inflammation, Antigen presentation and Vaccine Design. | |
WG4 | Audrey | Esclatine | France | Paris | Université Paris Sud CNRS-I2BC | Relationships between autophagy and viral infection. |
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WG5 | Aurelio | Hernández Laín | Spain | Madrid | Hospital Universitario 12 de Octubre | Clinical trials for patients with cerebral tumors. | |
WG1 | Aurelio | Serrano | Spain | Sevilla | CSIC Instituto de Bioquímica Vegetal y Fotosíntesis | Interest in the interplay between lumenal acidification and autophagy. Particularly in outline which is the involvement of the different types of proton pumps (H and V-ATPases-pyrophosphatase) in this process. Additionally, interested in physiologically relevant factors affecting the activity of these pumps and how this results in inhibition or induction of autophagy and other effects at the cellular level in model organisms such as yeast, Arabidopsis thaliana, and mammalian cell lines. | |
WG4 | Aurore | Rozières | France | Lyon | CSIC-Univ. de Sevilla, Instituto de Bioquímica Vegetal y Fotosíntesis | Autophagy in Crohn's disease | |
WG4 | Bassam | Janji | Luxembourg | Luxemburg | Luxembourg Institut Of Health | MC T | Investigate the role of autophagy in the regulation of the anti-tumor immune response under hypoxic stress. |
WG4 | Beata | Pajak | Poland | Warszawa | Mossakowski Medical Research Centre | MC T | The importance of autophagy in neurodegenerative diseases (AD), cancer, as well as metabolic syndrome. |
WG5 | Beata | Sikorska | Poland | Lodz | Medical University of Lodz | Our group is working on autophagy in prion diseases and neurodegeneration in humans | |
WG1/WG2/WG4/WG5 | Benjamin | Dehay | France | Bordeaux | IMN-CNRS UMR 5293 | DC L | Lysosomal Impairment, Parkinson's disease, Therapeutic approaches. |
Boris | Turk | Slovenia | Ljubljana | Jozef Stefan Institute | MC S | ||
WG3 | Béatrice | Satiat-Jeunemaitre | France | Gif sur Yvette | Institut de Biologie Intégrative de la Cellule - CNRS | Plant cell biology, Morphodynamics of cell comparment, autophagosome, Endomembranes. | |
WG4 | Carlos | Guillén | Spain | Madrid | Universidad Complutense de Madrid | mTORC1, SIRT1, insulin, amylin, aging, resveratrol, diabetes. | |
WG1 | Carole | Kretz-Remy | France | Villeurbanne | Université Claude Bernard Lyon I | Our group is interested in cell response to protein aggregation stresses. We have shown that upon protein aggregation stresses, NFkB transcription factor is activated and in turn induces autophagy, which participates in the clearance of protein aggregates accumulated in the cell. | |
WG1 | Catalina | Ribas | Spain | Madrid | Universidad Autónoma de Madrid | Our laboratory is investigating key nodes in signalling networks involved in prevalent age-related pathologies such as metabolic/cardiovascular diseases and cancer. | |
WG1/WG2/WG4 | Catalina | Ribas | Spain | Madrid | Universidad Autónoma de Madrid | Our laboratory is investigating key nodes in signalling networks involved in prevalent age-related pathologies such as metabolic/cardiovascular diseases and cancer. | |
WG4 | Caty | Casas | Spain | Barcelona | Universitat Autònoma de Barcelona | Chair | Endogenous mechanisms in retrograde motoneurodegeneration and axonal damage. |
WG3 | Cecilia | Gotor | Spain | Sevilla | CSIC Institut de Bioquímica Vegetal y Fotosíntesis | Arabidopsis, Cysteine, Sulfide, Plant Stress, Proteomic. | |
WG5 | Cecilia | Marelli | France | Montpellier | CHRU Gui de Chauliac | Aggregation-directed peptide therapy for Huntington's disease; stimulation of autophagy to eliminate free polyQ huntingtin protein | |
WG4 | Chantal M. | Boulanger | France | Paris | INSERM | Endothelial autophagy, senescence, cardiovascular diseases, inflammation, apoptosis, atherosclerosis, endothelial shear stress, endothelial function. | |
WG1 | Christian | Behrends | Germany | Frankfurt | Goethe University Frankfurt | MC T / SC VL | 1) Role of the family of human ATG8 proteins in autophagy and beyond. 2) Crosstalk between autophagy and the ubiquitin system. 3) Embedding of autophagy within the cellular endomembrane and trafficking system. 4) Upstream regulation of autophagy (mTOR signalling). |
WG4 | Christine | Connolly | Ireland | Dublin | Centre for bionano interactions | ||
WG4 | Christophe | Viret | France | Lyon | INSERM | AU-utophagy in infection and Crohn | |
WG5 | Christophe | Bauters | France | Lille Cedex | Université Lille Nord de France | Translational research in heart failure. | |
WG2 | Clara | Marquina | Spain | Zaragoza | CSIC-Universidad de Zaragoza | Nanotechnology & Autophagy: Influence of different types of nanomaterials (nanoparticles etc) on inducing autophagy. Characterization by nanotechnology tools (Dual Beam 3 Nova 200, advanced TEM techniques etc.) of cells after induced autophagy. Magnetic hyperthermia as trigger mechanism of autophagy. | |
WG1 | Clarisse | Berlioz-Torrent | France | Paris | INSERM | HIV, autophagy, non-canonical role of ATG proteins, LAP, selective autophagy, restriction factor, innate immunity. | |
WG1 | Claudine | Kraft | Austria | Vienne | University of Vienne | Signalling and molecular steps leading to autophagosome formation. | |
WG1 | Covadonga | Alonso | Spain | Madrid | Instituto Nacional de Invesigación y Tecnologia Agraria y Alimentaria | Studying the interface between endocytosis and autophagy and its relevance in the innate immunity against viruses. It has shown that interferon-induced proteins, which can inhibit the entry by endocytosis of several viruses are expressed in amphisomes. Using a double stranded DNA virus as a model, are investigated new targets for antivirals. Also, working in biofunctionalization of nanoparticles with virus-derived sequences in collaboration with Dr. Jesus M. de la Fuente group. Studying biocompatibility and toxicity of compounds and their impact in autophagy. | |
WG4 | Cécile | Vindis | France | Toulouse | INSERM | MC T | Exploring the role of mitophagy in atherosclerosis as a new target for plaque stabilization. |
WG4 | Céline | Gongora | France | Montpellier | IRCM, Institut de Recherche en Cancérologie de Montpellier; INSERM | Role of autophagy in drug resistance in cancer | |
WG3 | Céline | Masclaux-Daubresse | France | Versailles | Institut National de recherche Agronomique | Abiotic stress (N, S limitations), Nutrient recycling, Nitrogen remobilisation, Leaf senescence, Metabolism, 15N tracing. | |
Dan | Lindholm | Finland | Helsinki | University of Helsinki | MC T | Signaling Mechanisms and Organelle Dysfunctions in the regulation of Cell Death in neurons and in Neurodegenerative Diseases. Interested in signaling mechanisms for cell death in neurons and the role of cell death proteins, including the Inhibitor of Apoptosis Proteins (IAPs) in the control of neurodegeneration, in excitotoxic brain damage and in oxidative stress in the brain. Particular focus is on the role of mitochondria and endoplasmic reticulum (ER) stress in disease pathogenesis in neurological disorders, such as in amyotrophic lateral sclerosis (ALS) and Huntington´s disease (HD). Studying neuroinflammation and the roles played by peroxisome proliferator-activated receptor-gamma coactivators (PGC-1) and nuclear receptors in the regulation of cell viability and mitochondrial metabolism in neurons. | |
WG4/WG5 | Dan | Grandér | Sweden | Stockholm | Kaolinska Institut | Role in cancer and in sensitivity/resistance to anti-cancer therapy, screening of all anti-cancer drugs for autophagy induction, non-coding RNA in autophagy, biomarkers for autophagy in patients with cancer, development of novel anti-autophagy therapy. | |
WG4 | Daniel | Ruiz-Molina | Spain | Barcelona | CSIC Institut Català de Nanociència i Nanotecnologia | ||
WG2/WG3 | Daniel | Hofius | Sweden | Uppsala | Swedish University of Agricultural Sciences (SLU) | Plant-pathogen interactions, innate immunity; programmed cell death; host and pathogen targets of selective autophagy; viral pathogenesis and antiviral immunity; membrane trafficking; steroid signalling; epigenetic regulation; crosstalk with proteasome, stress and pathogen resistance in crop plants, plant biotechnology, translational and cross-kingdom approaches. | |
WG5 | Daria | Ler | Bosnia and Herzegovina | Sarajevo | PZU "Moja Klinika" | MC T | Identifying risk markers and elucidating pathways responsible for breast cancer cell proliferation is important for the improvement of the risk classification in patients as well as discovery of therapeutic targets. Currently, MACC1 protein expression studies in clinical-pathologically characterized breast cancer samples was evaluated only by immunohistochemistry and showed significant MACC1 expression associated with clinical stage and lymph node metastasis. We aimed to investigate potential role of MACC1 as an effective therapeutic target and to elucidate the possible role of MACC1 in breast cancer metastasis. Taken together, MACC1 harbors a great potential to be used in clinics as a prognostic marker for the identification of high-risk patients and could be used to predict cancer recurrence and therapy response. |
David | Prous | Spain | Barcelona | Prous Institut for Biomedical Research | |||
WG4 | David | Rubinsztein | United Kingdom | Cambridge | University of Cambridge | Basic autophagy biology, Drug discovery, Translation. | |
WG5 | Delia | Goletti | Italy | Roma | National institut for Infectious Diseases "Lazzaro Spallanzani" | MC S | impact of autophagy on M. tuberculosis. |
WG1/WG4 | Devrim | Gozuacik | Turkey | Tuzla | Sabanci University | MC T | Mammalian autophagy basic mechanisms. Autophagy regulating new proteins and pathways microRNA regulation of autophagy. Role of autophagy abnormalities in diseases (cancer, neurodegenerative diseases, stroke). Manipulation of autophagy for disease treatment. Use of nano particles as autophagy drug carriers. Innovative medical device/tool development and autophagy. |
WG5 | Diego | Tosi | France | Montpellier | ICM | Implementation of early clinical trials in cancer patients. | |
WG4 | Diego | Ruano Caballero | Spain | Sevilla | Universidad de Sevilla | Basic mechanisms. Age-related modifications. Role on neurodegeneration and cancer. Cross-talk Autophagy/Proteasomal suystem. ER-stress-UPR-Autophagy. | |
WG1 | Eeva-Liisa | Eskelinen | Finland | Helsinki | University of Helsinki | MC T | High-resolution 3D imaging of forming autophagosomes and role of the small GTPase RAB24 in autophagy. |
WG1 | Elah | Pick | Israel | Tivon | University of Haifa | MC T | Activation and activity of the COP9 signalosome (CSN); CRLs activity; developing CSN readout assay; NEDDylation/deneddylation; The CSN in stress, cancer and neurodegeneration. The CSN/NEDD8 axis upon oxidative stress. Regulation of sterol production and membrane fluidity by the CSN. Regulation of Autophagy by the CSN. |
WG1/WG4 | Elżbieta | Kania | Poland | Warsaw | KU Leuven | Calcium signaling and metabolic pathways during autophagy in cancer and neurodegenerative disorders. | |
WG5 | Enzo | Emanuele | Italy | Robbio | 2 E SCIENCE | I work on the application of autophagy in skincare products, as well as on autophagy markers in longeve individuals. | |
WG3 | Erika | Isono | Germany | Freising | Technische Universität Münich | Intracellular trafficking, endocytosis, Autophagy, Biochemistry, Cell biology. | |
WG1 | Esther | Dalfó | Spain | Barcelona | Universitat Autònoma de Barcelona | function and the metabolic influence in the regulation of neurodegenerative |
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WG4 | Eva | Zerovnik | Slovenia | Ljubljana | Institut Jozef Stefan | MC T | To get to know the molecular basis of neurodegenerative diseases, our lab is interested in cellular consequences of protein aggregation, such as recruitment of chaperones and autophagy. We concentrate on stefin B from the family of cystatins. Other processes of interest are aggresome formation, lysosomal and mitochondrial pathways of cell death and innate immune response. |
Eva | Sjøttem | Norway | Tromsø | University of Tromsø | MC S | ||
WG1/WG4/WG5 | Fabio | Penna | Italy | Torino | University of Torino | Cancer cachexia, skeletal muscle, wasting, hypercabolism, mitochondria. | |
WG4 | Fatima | Mechta-Grigoriou | France | Paris | Institut Curie | Role of autophagy in triple-negative breast cancers. | |
WG4 | Felipe X. | Pimentel-Muiños | Spain | Salamanca | Centro de Investigación del Cáncer. Universidad Salamanca. CSIC | Molecular mechanisms involved in atypical autophagy against single membrane subcellular structures. Involvement of Atg16L1 in autophagy against infectious agents (xenophagy). Molecular bases of Crohn's disease. | |
WG3 | Fernanda | Suárez Marín | Spain | Málaga | Universidad de Málaga | Programmed cell death, autophagy, metacaspase, plant embryo development. | |
WG2 | Fernando | Novio Vázquez | Spain | Barcelona | CSIC Institut Català de Nanociència i nanotecnologia | Design, synthesis and characterization of nanoconstrucs as nanocontainers for different drugs and active species. Interest in the modulation of macroautophagy-lysosomal system (MALS) disorders for the treating of different diseases using nanoparticles. | |
WG4 | Filippo | Bertoli | Ireland | Dublin | CBNI, University College Dublin | ||
WG4 | Florence | Pinet | France | Lille | INSERM | MC S | 1) Cardiovascular diseases, mainly heart failure. 2) Mechanisms of autophagy in link with our proteomic data sets obtained from human cohorts of patients and experimental animal models of heart fialure. 3) Translational research with availility oh human samples dedicated to our reaserch project. 4) Close link with clinicians (cardiologists, vascular surgeons) |
WG1/WG2 | Florian | Gruber | Austria | Vienne | Medical University of Vienna | MC S | The main line of investigation is the generation, biological activities and degradation of oxidized lipids. Oxidized lipids are emerging as potent signaling mediators in the biology of aging, stress and inflammation of the skin. Oxidative stress is highly relevant to the biology of the skin as it is the organ most exposed to environmental stressors like ultraviolet light. For tath reason, the principal researh is in the interaction of oxidized lipids with the cellular stress response machineries, e.g. the Nrf2 response and autophagy. |
WG1 | Francesca | Demarchi | Italy | Trieste | Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (CIB) | My current project aims to study the molecular intersection between autophagy, the ubiquitin-proteasome system and the calpain/calpastatin system in the context of tumor biology and in prospective of the design of novel therapeutic strategies against autophagy-dependent tumors. | |
WG4/WG5 | Francesco | Cecconi | Denmark | Copenhagen | Kraeftens Bekaempelse | MC S | Working on the elucidation of the upstream autophagy regulation pathways, focussing on protein post-translational modifications (phosphorylation, sumoylation, ubiquitylation) and autophagy complexes' formation. In cancer, it is testing a set of Ambra1- (or Ambra1 cofactors, such as ULK1, TRAF6, DLC1 or PP2A) interfering small peptides for their ability to regulate autophagy in tumor-model cell lines of the lung, breast and melanoma. Also, it is producing autophagy-related mouse systems to test compunds in vivo. |
WG3 | Francisca | Sevilla | Spain | Murcia | CSIC Centro de Edafología y Biología Aplicada del Segura | Arabidopsis, Pisum, redox proteins, mitochondria, proteomic, Plant stress, developement. | |
WG1/WG4 | Francisco | Wandosell | Spain | Madrid | CSIC Centro Biologiía Molecular Severo Ochoa | Neurodegeneration, Neuritogenesis , Neuronal morphogenesis, Alzheimer, Ischemia, Neuronal and Glial signalling. | |
WG1/WG2 | Frank | Lafont | France | Lille | CNRS- (UMR8204) | MC S / WG2 VL | Host-pathogen interaction, cellular microbiology, membrane traffic, biophysics, imaging technologies, nanotechnologies. |
WG4 | Frank | Lezoualc'h | France | Toulouse | INSERM | To study new signaling pathways induced by adrenergic stimulation and involved in Aging and the development of Heart Failure. Our major goal is to better understand how those signaling pathways (i.e cAMP-Epac, monoamine oxidase-A) interfere with autophagy to regulate cardiomyocyte fate (cell death, hypertrophy, senescence) in the heart. By improving autophagy, we aim at counteracting the deleterious mechanisms associated with cardiac dysfunction such as cardiomyocyte death and mitochondrial damage | |
WG3 | Frantisek | Baluska | Germany | Bonn | University of Bonn- IZMB | Cytoskeleton, Signaling, Endocytosis, Myotubularins, Root Cells, Imaging. | |
François | Ichas | France | Pessac | Fluofarma | |||
WG1/WG4 | Fulvio | Reggiori | Netherlands | Groningen | University of Groningen, University Medical Center Groningen | MC T | Study of the regulation and mechanism of autophagy using yeast as a model system. Study the role of autophagy during viral infections. |
WG1 | Félix M. | Goni | Spain | Bilbao | Universidad del País Vasco | Reconstitution of autophagosomal growth from defined components (pure human proteins and lipids); molecular interactions between autophagy-related proteins and membranes. | |
WG1/WG4 | Gabor | Juhasz | Hungary | Budapest | EOTVOS Lorand University | MC T | Roles and molecular mechanisms of autophagy in Drosophila. |
WG1 | Gabor | Banhegyi | Hungary | Budapest | Semmelweis University | Investigation of the role of autophagy in the intermediary metabolism with special emphasis on glycogenolysis. Glycophagy under normal conditions and in glycogen storage diseases. Effects of autophagy modulating agents on carbohydrate metabolism. | |
WG1 | Gian Maria | Fimia | Italy | Roma | National institut for Infectious Diseases "Lazzaro Spallanzani" | MC S | Regulation of autophagy induction; Crosstalk between autophagy and the ubiquitin proteasome system; Role of autophagy in infectious diseases (HCV, HIV, MTB). |
WG1 | Giulia | Riparini | Italy | Urbania | University of Urbino Carlo Bo | Autophagy and endoplasmic reticulum stress in neurodegeneration and neuroprotection after perinatal brain damage | |
WG1 | Giuseppe | Buonocore | Italy | Siena | University of Siena | Role of authophagy in the newborn. | |
WG2 | Giuseppe | Maulucci | Italy | Roma | Università Cattolica del Sacro Cuore | Working in the field of functional imaging, on the relationship between redox state and the physical state of biomembranes mediated by lipid peroxidation products. Recently developedment of a method of confocal analysis that allow the quantification of the autophagic flux. | |
WG4 | Guido | Kroemer | France | Paris | INSERM | Studying pharmacological, genetic, nutritional or behavioral interventions that induce autophagy and that may have positive effects on normal or pathological aging, as well as several major diseases (cancer, neurodegeneration) and the most frequent "rare" diseases (cystic fibrosis and Wilson disease). | |
WG1/WG2/WG4/WG5 | Guillermo | Velasco Díez | Spain | Madrid | Universidad Computense de Madrid | MC S / WG4 L | Role of autophagy in cancer, sphingolipids, autophagy-mediated cancer cell death, autophagy signalling. |
WG3 | Hadas | Zehavi | Israel | Rehovot | Weizzmann Institute of Science | "My work is mainly focused on a plant-specific ATG8-binding cargo receptor (ATI1) that is induced under stress and involved in the recycling of chloroplast proteins and possibly in ER to vacuole trafficking. ATI1 represents an interes ng path of autophagy, as it is ini ally associated with vesicles that defer from classic autophagosomes, but clearly requires ATG8 and the autophagic machinery to get to the vacuole. We are aiming to elucidate its physiological role under normal growth condi ons and under stress, as well as its rela on to the autophagy machinery and its trafficking to the vacuole." |
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WG4 | Hang | Nguyen | France | Clermont-ferrand | INSERM | To investigate the role of autophagy in host responses to infection with bacteria associated to Crohn's disease. | |
WG4 | Hans-Uwe | Simon | Switzerland | Bern | University of Bern | To determine the role of autophagy in the pathogenesis of inflammatory diseases and cancer. | |
WG1 | Harald | Wodrich | France | Bordeaux | Université de Bordeaux | "My group is interested in how viruses overcome intrinsic immunity mechanisms during entry. In this respect we have very nice ongoing work demonstra ng how membrane ly c adenoviruses elicit and limit membrane damage induced selec ve autophagy. I am also a cofounder of the Club Bordelais d'Autophagy (CAB), which is the local organizing commiFee for this years annual French Autophagy mee ng (CFATG) in Bordeaux." |
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WG4/WG5 | Heinz | Jungbluth | United Kingdom | London | KIng's College London | MC S | Peadiatry |
Helena L. A. | Vieira | Portugal | Lisboa | CEDOC, Facultdade de Ciencias Medicas Universidad Nova de Lisboa | MC T | Mitophagy related to: Mitochondrial quality control, Mitochondrial turnover, metabolism modulation and cytoprotection. Role of mitophagy in chronic and acute neurodegeneration, such as cerebral ischemia and repercussion. We are interested in understanding the molecular mechanisms underlying mitophagy and in particular mitophagy in response to stress, namely metabolic and inflammatory responses following ischemia. | |
WG4 | Helga | Ogmundsdottir | Iceland | Reykjavik | University of Iceland | MC T | Interested in various aspects of the cell biology of breast cancer, including cytogenetics of breast cancer. Also molecular changes in mucosal lesions in the mouth and oral cancer. Furthermore, projects linking the study of immunology and malignancy, studying the genetic and biological basis of B-cell-derived malignancies. In a long-standing collaboration with the Faculty of Pharmaceutical Sciences the effects of lichen-derived compounds on cancer cells have been investigated. Biobank-based research on cancer causes in international collaborations. Finally, a small project on the effect of loss of the thymus during cardiac surgery in infancy on T-cell function. |
WG1/WG3 | Henri | Batoko | Belgium | Louvain-la-Neuve | Université catholique de Louvain | MC T / WG3 L | Understand the role, molecular mechanism and regulation of selective autophagy during abiotic stress in the plant cell. |
WG1/WG4 | Henrique | Girao | Portugal | Coimbra | Faculty of Medicine University of Coimbra-IBILI | MC T | Working on the molecular mechanisms involved in ubiquitin-dependent autophagy degradation of membrane proteins; cross talk endocytosis - autophagy; autophagy in heart in health and disease; autophagosome biogenesis. |
WG1/WG2/WG4/WG5 | Ioannis | Trougakos | Greece | Athens | National & Kapodistrian University of Athens, | MC S | MCAC focuses on proteome stability alterations during ageing and in age‐related diseases, as well as in the discovery of natural compounds that reduce proteome aggregation and prolong proteome stability and longevity at either cell‐based and/or at in vivo experimental models. |
WG1 | Ioannis P. | Nezis | UK | Coventry | University of Warwick | Molecular mechanisms of selec6ve autophagy in health and disease | |
WG4 | Iraide | Alloza | Spain | Bilbao | Universidad del País Vasco | Autophagy Biomarkers in Aterosclerosis | |
WG4 | Isabelle | Vergne | France | Toulouse | PBS-CNRS | MC S | The primary objective is to decode the regulation and the role of autophagy in myocbacterial infections, such as Tuberculosis, in order to propose novel vaccines and therapeutics based on autophagy. |
WG1 | Ivan | Dikic | Germany | Frankfurt | Goethe University Frankfurt | Molecular characterisation of autophagy pathway. selective autophagy receptors and adaptors. | |
WG1/WG4 | Ivana | Novak Nakir | Croatia | Split | School of Medicine, University of Split | MC T | |
WG1 | James | Murray | Ireland | Dublin | Trinity College Dublin | MC T / TKC L | Mechanisms of autophagy regulation and control through reversible lipid and protein phosphorylation; enzymology, signalling kinases and cell ageing and ageing-related diseases. |
WG1 | Jan B. | Parys | Belgium | Leuven | Dept. Cellular and Molecular Medicine & Leuven Kanker Instituut | Investigation of the role and the targets of Ca2+ intracellularly released by the endoplasmic reticulum and/or the lysosomes in the regulation of autophagy. | |
WG1 | Jan | Martinec | Czech Republic | Prague | The Czech Academy of Sciences | MC T | Focused to unravelling of molecular mechanism of lipids and lipid-metabolizing enzymes involvement in plant autophagy induced by stress conditions |
WG1 | Jason | King | United Kingdom | Sheffield | University of Sheffield | Understanding molecular mechanisms of autophagy, and its regulation. | |
WG4 | Javier | Díaz-Nido | Spain | Madrid | Universidad Autónoma de Madrid | Neurodegeneration. Mitophagy. Friedreich's ataxia. | |
WG1 | Jelena | Stankovic | Serbia | Belgrade | University of Belgrade | Testing new compounds, their anti-proliferative capacity and mechanisms involved in this process | |
WG4 | Jelena | Dinic | Serbia | Belgrade | Institute for Biological Research "Sinisa Stankovic" | MC T | Targeting multidrug resistance (MDR) in cancer, mainly the evaluation of new autophagy modulators and inhibitors of P-glycoprotein function as anticancer drug candidates. Special attention is given to autophagy as one of the mechanisms of MDR, and the potential solutions for overcoming of this phenomenon. We utilize MDR human and animal cell lines as models for studying the anticancer effects and the mechanisms of action in wide range of new natural, synthetic and semi-synthetic agents. |
WG1/WG3 | Jerome | Joubès | France | Villenave d'Ornon | Université Bordeaux Segalen | Identification of the lipids associated with autophagy and characterization of the molecular mechanisms controlling their mobilization and their functions in plant stress responses. | |
WG5 | Jessica | Martinsson | Sweden | Huddinge | Sprint Bioscience | Identifying autophagy inhibitors targeting Vps34 as cancer treatment. Program currently in lead optimization after a successful proof-of-principle study in vivo. | |
WG2 | Jesús | M de la Fuente | Spain | Zaragoza | CSIC Instituto de Ciencia de Materiales de Aragón | MC T / TKC VL | Study of nanoparticle-cell interactions, study of endocytosis mechanisms, photothermal Therapy, Magnetic Hyperthermia. Funcionalización de superficies para el desarrollo de procesos de adhesión celular y reconocimiento molecular, y por otro lado, la preparación, caracterización y biofuncionalización de nanopartículas metálicas para su empleo en biosensores y terapia tumoral. La modificación química de la superficie de las nanopartículas o de las diferentes superficies, así como la modificación de las proteínas o carbohidratos a unir es un requisito indispensable para una biofuncionalización adecuada de estos materiales para su uso en el desarrollo de nanobiosensores. A pesar de tener una amplia experiencia en la preparación de estos materiales, es en el ámbito de su funcionalización con moléculas de interés biológico (enzimas, anticuerpos, sondas de ADN, etc) donde se centra nuestra investigación. |
WG4 | Jesús | Ruberte | Spain | Barcelona | Universitat Autònoma de Barcelona | Study the role of autophagy during aging and disease in retinal blood vessels | |
Joan | Ballesteros | Spain | Vivia Biotech Sl | ||||
WG1 | Joanna | Kamińska | Poland | Warsaw | Institute of Biochemistry and Biophysics PAS | MC S | |
WG1 | Joern | Dengjel | Germany | Freiburg | University of Freiburg | Autophagosome, signaling, proteomics, protein turnover, mitophagy. | |
WG1 | Jon | Lane | United Kingdom | Bristol | University of Bristol | MC T / WG1 L | Molecular regulation of autophagosome assembly; ATG4 proteins; erythropoiesis; neurodegeneration; iPSC. |
WG1 | Jordi | Alcaraz | Spain | Barcelona | Universitat de Barcelona | Studying the role of tumor associated fibroblasts (TAFS) in lung cancer progression | |
WG1/WG2/WG5 | Jordi | Alcaraz | Spain | Barcelona | Universitat de Barcelona | Studying the role of tumor associated fibroblasts (TAFS) in lung cancer progression | |
WG1/WG2/WG5 | Jordi | Alcaraz | Spain | Barcelona | Universitat de Barcelona | Studying the role of tumor associated fibroblasts (TAFS) in lung cancer progression | |
WG4 | Josefina | Casas Brugulat | Spain | Barcelona | CSIC | Lipids. Lipidomics. Design, synthesis and evaluation of inducers/inhibitors of autophagy. Development of high throughput screening methods. | |
WG1/WG5 | José A. | Sánchez Alcázar | Spain | Sevilla | Universidad Pablo de Olavide | Mitophagy | |
WG4 | José M. | Fuentes | Spain | Cáceres | Universidad de Extremadura | Autophagy and Parkinson's disease. Role of PARK genes and environmental factors. | |
WG4 | José M. | García Fernández | Spain | Cartuja | CSIC Instituto de Investigaciones Químicas | Design of molecules interfering with lysosomal glycosidases involved in metabolic disorders implying autophagy deregulation. Development of pharmacological chaperones and nanodevices for the treatment of lysosomal storage disorders (Gaucher, Fabry, GM1 gangliosidosis, Tay-Sachs). Effect of pharmacological chaperones in autophagy and implementation of chaperone therapies and combined therapies. | |
WG4 | José M. | Lizcano | Spain | Barcelona | Universitat Autònoma de Barcelona | Dissection of new signaling pathways in cancer and developing new antitumor drugs. | |
WG | José M. | Jerez Aragonés | Spain | Málaga | Universidad de Málaga | Detecting autophagy prognostic signature in cancer. | |
WG1 | José-Luis | Crespo | Spain | Sevilla | CSIC | Redox regulation of autophagy by stress and chloroplast damage in photosynthetic eukaryotes using the unicellular green alga Chlamydomonas reinhardtii as model system. | |
WG2 | José-María | Sánchez-Puelles | Spain | Madrid | CSIC | Target validation for drug discovery, autophagy & aging. | |
WG5 | Juan | Sepúlveda Sánchez | Spain | Madrid | Hospital Universitario 12 de Octubre | Clinical trials for patients with cerebral tumors. | |
WG4 | Juan | Iovanna | France | Marseille | INSERM | TC SA | Pancreatic cancer. |
WG5 | Juan A. G. | Ranea | Spain | Málaga | Universidad de Málaga | Bioinformatics and biology network associations. | |
WG4 | Julia | Lorenzo | Spain | Barcelona | Universitat Autònoma de Barcelona | Bioengineering | |
WG4 | Julien | Puyal | Switzerland | Lausanne | University of Lausanne,Department of Fundamental Neurosciences, Puyal- Truttmann Lab | MC S | Neuroprotection ,Cerebral hypoxia-ischemia, excitotoxicity, neuronal death |
WG4 | Kathrin | Pallauf | Germany | Kiel | Institute of Human Nutrition and Food Science (University of Kiel) | Studying the impact of potential autophagy-inducing agents (e.g. resveratrol) found in dietary plants on ageing-related processes. | |
WG4 | Kenneth A. | Dawson | Ireland | Dublin | University college Dublin | Nanomaterial interactions with organisms. | |
WG4 | Kevin | Ryan | United Kingdom | Glasgow | Cancer Research UK Beatson Institut | Role of autophagy in cell death and cancer. | |
WG1 | Krassimira | Todorova-Hayrabedyan | Bulgaria | Sofia | Bulgarian Academy of Sciences | MC S | Effect of micro-RNAs (hsa-miR-204) on autophagy modulation in prostate cancer |
WG1 | Lenka | Gemperlová | Czech Republic | Prague | Institute of Experimental Botany | MC S | The first area concerns plant developmental processes studied especially on the system of coniferous somatic embryogenesis. Since autophagy is an integral part of the suspensor cell death in plant embryogenesis, we plan to study in details the early somatic embryo development phase in gymnosperms. The second part includes the effect of polyamines on the cell growth, plant cell cycle and plant responses to abiotic stresses |
WG4 | Leonidas | Stefanis | Greece | Athens | Biomedical Research Fondation Of the Academy of Athens | MC T | Deciphering the involvement of autophagic pathways in neurodegenerative diseases, in particular Parkinson's Disease and related synucleinopathies; using this knowledge to devise novel therapeutic strategies based on modulation of autophagy, and in particular Chaperone-Mediated Autophagy (CMA). |
WG1/WG4 | Leopold | Eckhart | Austria | Vienna | Medical University of Vienna | MC T | Autophagy in epithelial cells. |
WG1 | Lisa | Frankel | Denmark | Brønshøj | University of Copenhagen | Interconnection between RNA and autophagy. In particular, working with RNA binding proteins that impact on the autophagy signalling pathway. | |
WG1 | Lucie | Fischerová | Czech Republic | Prague | Institute of Experimental Botany | Molecular characterization of plant polyamine metabolism. The connection of polyamines and autophagy studied in the model system of coniferous somatic embryogenesis. | |
WG1 | Ludwig | Eichinger | Germany | Köln | University of Cologne | "Our main research interest is the analysis of the molecular mechanism of autophagy in D. discoideum. In particular, we are interested in the link between autophagy and the proteasome, the role of autophagy in host-pathogen interactions and in non-autophagic functions of core autophagy proteins." |
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WG3 | Luisa M. | Sandalio | Spain | Granada | Consejo Superior de Investigaciones cientificas. Estación Esperimental del Zaidin | Peroxisomes, biotic and abiotic stress, imaging, reactice oxygen and nitrogen species. | |
WG3 | M. Gonzalo | Claros Díaz | Spain | Málaga | Universidad de Málaga | Detemine which biomarkers and genes are involved, and how are involved, in autophagy. | |
WG2 | M. Ricardo | Ibarra García | Spain | Zaragoza | Universidad de Zaragoza | Influence of different types of nanomaterials (nanoparticles etc) on inducing autophagy. Characterization by nanotechnology tools (Dual Beam 3 Nova 200, advanced TEM techniques etc.) of cells after induced autophagy. Magnetic hyperthermia as trigger mechanism of autophagy. | |
WG4 | Marcello | Pinti | Italy | Modena | Universita Di Modena e Reggio Emilia | Effects of antiretroviral drugs used in HIV treatment on autophagy and mitophagy, particularly in adipocytes. | |
WG4 | Marco | Sandri | Italy | Padova | University Of Padova-Venetian Institut of Molecular Medicine | Defining the role of autophagy in acquired and inherited cardiac and skeletal muscle diseases. | |
WG1 | Margret | Ogmundsdottir | Iceland | Reykjavik | University of Iceland | MC T | |
WG4/WG5 | Maria | Xilouri | Greece | Athens | Biomedical Research Foundation of the Academy of Athens | MC S | Pathogenesis of neurodegenerative diseases with an emphasis on the interrelationship between aggregated-prone proteins such as alpha-synuclein, MAPT/tau or beta-amyloid, to lysosomal degradation pathways. |
WG1/WG4/WG5 | Maria Cristina | Albertini | Italy | Urbino | University Of Urbino "Carlo Bo" | MicroRNAs involved in the epigenetic regulation of autophagy. | |
WG4 | Mario | Chiariello | Italy | Siena | Consiglio Nazionale Delle Ricerche | Regulation of autophagy by MAP kinase. | |
WG4 | Mario | Cordero | Spain | Sevilla | Universidad de Sevilla | Autophagy in aging and rare diseases. | |
WG4/WG5 | Mario P. | Tschan | Switzerland | Bern | University of Bern | MC T | Cell Differentiation, physiology an dynamics. |
WG4 | Marja | Jäättelä | Denmark | Copenhagen | Danish Cancer Society | MC T | Molecular mechanisms of autophagy, focus on cancer, signalling pathways and lipids. |
WG4 | Markus | Rehm | Germany | Stuttgart | University of Stuttgart | Functional, mechanistic and kinetic understanding at the level of signaling systems; Identification of combinatorial systems biomarkers and development of innovative stratification tools. | |
WG2/WG4/WG5 | Marta | Martínez-Vicente | Spain | Barcelona | Vall d'Hebron Institut de Recerca | MC S | Neurodegeneration, Parkinson, Huntington, therapy, nanotechnology. |
WG4 | Martine | Biard-Piechaczyk | France | Montpellier | Centre d’études d’agents Pathogènes et Biotechnologies pour la Santé | Autophagy during viral infections, mainly HIV-1 infection. The aim is to better understand the interactions between HIV-1 and autophagy in critical immune cells of the host in order to open new avenues for therapeutic and prophylactic strategies. | |
WG5 | María | Morán | Spain | Madrid | Instituto de investigación Hospital 12 de Octubre | MC T / WG5 L | Mitochondrial diseases, autophagy modulation, therapy, muscle wasting, neurodegeneration. |
WG1/WG5 | María | Soengas | Spain | Madrid | Spanish National Research Centre | WG5 SA | Molecular basis of melanoma progression and response to therapy. |
WG4 | María Luz | Martínez Chantar | Spain | Derio | CIC bioGUNE | Autophagy in fatty liver disease. | |
WG4 | Mathias | Faure | France | Lyon | INSERM, CNRS - Université Lyon | MC S / WG4 VL | Function and regulation of autophagy in infections and immunity. |
WG4 | Matthew | Gegg | United Kingdom | London | University College London | Understanding how impairment of autophagy-lysosome pathway contributes to Parkinson's disease pathogenesis. | |
WG2 | Mattia | Mori | Italy | Roma | Istituto Italiano di Tecnologia [Center for Life Nano Science] | MC T | Design/optimization of small molecules; drug discovery; computational structural studies on target proteins; in silico mutagenesis; computational folding studies; natural products; medicinal chemistry. |
WG5 | Maurizio | Muscaritoli | Italy | Roma | Sapienza Università di Roma | Role of autophagy in muscle wasting. | |
WG4 | Michael | Thumm | Germany | Göttingen | Georg August universität, Universitatsmedizin | Molecular mechanism on autophagy in S.cerevisiae. | |
Michael | Glickman | Israel | Haifa | Technion -IIT | MC T | ||
WG3 | Michele | Wolf Bianchi | France | Lyon | CNRS | Autophagosome Formation, Imaging, Abiotic Stress. | |
WG4 | Miguel Antonio | López Pérez | Spain | Santiago de Compostela | Universidad Santiago de Compostela | Autophagy in hippotalamus control of obesity and metabolism. | |
WG5 | Miguel Ángel | Martín | Spain | Madrid | Servicio Madrileño de la salud. Hospital 12 de Octubre | Diagnosis and physiopathology of mitochodrial diseases and other neuromuscular disorders, the role of autopahagy in these diseases. | |
WG5 | Mirza | Suljagic | Bosnia and Herzegovina | Sarajevo | International University of Sarajevo | MC T | We are studying apoptosis and autophagy regulatory proteins in Chronic myelogenous leukemia (TKI sensitive vs. TKI resistant) and Diffuse large B cell lymphoma (GC vs. ABC origin). We are targeting selected regulatory pathways with our candidate compounds for improving current treatment options. |
WG4 | Mograbi | Baharia | France | Nice | Institut National de la sante et de la recherche médicale INSERM- IRCAN | Autophagy process at molecular, cellular and integrative levels in order to delineate (i) the link between autophagy, ageing and chronic diseases, (ii) the susceptibility to intrinsic (epigenetic) and extrinsic (nutrition, pollutants, carcinogens) factors and (iii) first-in-class therapies that will improve healthy ageing, slow and prevent ageing diseases (specifically cancer). | |
WG4/WG5 | Mojgan | Djavaheri-Mergny | France | Bordeaux | INSERM- INSERM U916 | Deciphering the role of autophagy in cancer cells. | |
WG2 | Monika | Cahova | Czech Republic | Prague | Insititut For Clinical and Experiental Medicine | 1) the evolution of mitochondrial changes in pancreatic β-cells in different experimental models of type-2 diabetes, with respect to the alterations in mitophagy. 2) the role of (dys)regulation of autophagy in the development of type-2 diabetes-related metabolic disorders, particularly liver steatosis. | |
WG3 | Morten | Petersen | Denmark | Copenhagen | Copenhagen University- Faculty of science | MC S | Innate immunity, autophagy, MAP kinase signaling, development, |
WG4 | Nadezda | Apostolova | Spain | Valencia | Universitat de Valencia | WG4 SA | Autophagy related to HIV infection and antiretroviral drugs. |
WG1 | Nadine | Camougrand | France | Bordeaux cedex | Institut de Biochimie et Génétique Cellulaires | Study of mitophagy in the yeast Saccharomyces cerevisiae. | |
WG1/WG2/WG4 | Nektarios | Tavernarakis | Greece | Heraklion | Foundation for Research nd Technology-Hellas | MC T | Ageing, Cell Death, Mitophagy, Neurodegeneration, Pexophagy, Stress Responses. |
WG1 | Nicholas | Ktistakis | United Kingdom | Cambridge | Babraham Institut | Mechanisms of autophagy induction; signaling during autophagy; discovery of small molecules regulating autophagy. | |
WG4 | Nicolas | Pallet | France | Bordeaux | INSERM | Autophagy in kidney disease; autophagy in renal stress response; autophagy and endoplasmic reticulum stress | |
WG4 | Nicolas | Deconinck | Belgium | Gent | Hôpital Universitaire des Enfants Reine Fabiola | Mechanisms of autophagy at play in neuromuscular disorders, in particular in COL VI myopathies. | |
WG2 | Nikolai | Engedal | Norway | Oslo | University of Oslo | MC T / TKC VL | 1) Regulation of autophagy by calcium perturbation, ER stress signaling and the unfolded protein response 2) Intersections between autophagy and apoptosis 3) Specific roles and mechanisms of action of mammalian Atg8 proteins in autophagy |
WG3 | Núria | Sánchez Coll | Spain | Barcelona | Center for research in agricultural Genomics | Biotic stress, Programmed cell death. | |
WG4 | Patrice | André | France | Lyon | Centre International de Recherche en Infectiologie | Development of host-oriented antiviral molecules. | |
WG1/WG5 | Patrice | Codogno | France | Paris | INSERM | MC T / Vice Chair | Membrane dynamics of autophagosomal compartment. Interplay between autophagy and the primary cilium: role in mechanical stress integration. Role of autophagy in self-renewal of cancer stem cells and their targeting in breast cancer treatment. |
WG4 | Patricia | Boya | Spain | Madrid | CSCI | MC S / SC L | Role of autophagy during development and disease, focus on neurons. |
WG4 | Patrick | Auberger | France | Nice | INSERM | Targeting autophagy in hematopoietic malignancies and deciphering the role of autophagy in hematopoeitic cell differentiation | |
WG1 | Patrizia | Agostinis | Belgium | Leuven | University of Leuven/KU Leuven | MC T / WG1 VL | Melanomagenesis, angiogenesis, lymphangiogenesis, crosstalk cancer cell-stromal cells, mitophagy and metabolism, role of cancer cell-associated autophagy in therapy resistance, role of autophagy in immunogenic cell death and release of cytokines/chemokines. |
WG4 | Pattingre | Sophie | France | Montpellier | INSERM | Posttranslational modifications of atg proteins and cancer. | |
WG5 | Paul | Hofman | France | Nice | Institut for Recherch on Cancer and Aging, Nice (INSERM) | Tumor Bank | |
WG5 | Paulina | Langa | Poland | Gdansk | Medical University of Gdansk | "My primary research interests are mostly in the area of stem cells and transla onal medicine. I am currently op mising a protocol for transplan ng in vitro cultured epidermal cells in the treatment of chronic wounds a7er burns and diabe c ulcers." |
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WG4/WG5 | Penny | Lovat | United Kingdom | Newcastle Upon Tyne | Newcastle University | MC T | To define and validate novel autophagy biomarkers and drug targets to aid stratified medicine and the development of more efficacious therapeutic strategies to harness autophagy modulation for the clinical benefit of cancer, in particular melanoma and SCC. |
WG3 | Peter | Bozhkov | Sweden | Uppsala | Swedish University of Agricultural Sciences (SLU) | Aging, Plant development, Programmed cell death, Catabolism. | |
WG4 | Pierre-Emmanuel | Rautou | France | Paris | Inserm- INSERM U970 | Translation. Role of autophagy in liver disorders and role of autophagy in endothelial cells. | |
WG3 | Pilar S. | Testillano | Spain | Madrid | Biological Research Center (CIB), Spanish National Research Council (CSIC) | Autophagy in plant development, abiotic stress, plant programmed cell death, bioimaging, cell biology. | |
WG4 | Priault | Muriel | France | Bordeaux | Centre National de Recherche Scientifique CNRS | Autophagy, cancer, trafic, mitochondria, Bcl-xL, Rab7. | |
WG4 | Pura | Muñoz-Cánoves | Spain | Barcelona | Universitat Pompeu Fabra | Understanding how autophagy is altered in aging and disease using skeletal muscle stem cells as a model system. | |
WG1 | Radostina | Alexandrova | Bulgaria | Sofia | Museum-Bulgarian Academy of Sciences (IEMPAM-BAS) | MC T | Working in the field of experimental oncology and oncopharmacology. Establishment and morphological and functional characterization of model systems (primary cultures and permanent cell lines, including drug resistant cell lines), evaluation of antitumor activity of synthetic compounds and natural products and attempts to identify their molecular/cellular targets and mechanisms of action |
WG4 | Rafael | Delgado Vázquez | Spain | Madrid | Institut de Investigación Hospital 12 de Octubre | HIV and Ebola models. | |
WG1/WG2/WG5 | Raphaël | Rodriguez | France | Paris | Institut Curie | Identify small molecule regulators of autophagy. | |
WG4 | Raquel | Lima | Portugal | Porto | IPATIMUP/i3S | MC S | Modulation of autophagy for cancer therapy |
WG1/WG4 | Regina | Menezes | Portugal | Oeiras | Estação Agronómica Nacional - Edificio iBET/ITQB | MC S | Interests focused on translational science mainly (1) the dissection of the molecular mechanisms underlying Islet Amyloid PolyPeptide (IAPP) cytotoxicity in DIABETES MELLITUS – type 1 and 2 as well as pancreas transplantations – and (2) the identification/deep characterization of PROTECTIVE PHYTOCHEMICALS. For that, investing huge efforts in the development of amenable disease models aiming at exploitation of new therapeutic strategies |
WG1 | Renaud | Legouis | France | Saclay | CNRS | Understand the physiological roles of autophagy in C. elegans life cycle (development and aging). Analyse the specific roles of LC3 family in autophagy mechanisms. | |
WG5 | Ricardo | Pereira | Portugal | Coimbra | Centro Hospitalar e Universitario de Coimbra | ||
WG4 | Ricardo | Sánchez-Prieto | Spain | Albacete | Universidad de castilla de la Mancha | Role of autophagy in cancer therapy. | |
WG1 | Ricardo | Escalante | Spain | Madrid | CSIC | Mechanisms of autophagy. Origin of autophagosomes. Functional and comparative Genomics using Dictyostelium discoideum and Mammalian cells as model systems in pathology to identify and characterize novel genes involved in autophagy. Function of VPS13 proteins and their role in Chorea-acanthocytosis and autophagy. | |
WG5 | Rui | Baptista | Portugal | Coimbra | Faculty Of Medicine University of Coimbre | Translational projects that intend to investigate the role of autophagy in the maintenance of protein homeostasis in the heart. | |
WG1 | Rune | Matthiesen | Portugal | Lisboa | Institut Nacional de Saude Dr Ricardo Jorge (INSA,I.P.) | Interested in exploring the use of state of art mass spectrometry in combination with transfected cell lines to study drug induced autophagy in relation to drug resistance. |
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WG1/WG4 | Rüta | Navakauskienè | Lithuania | Vilnius | Vilnius University | MC S | Studies of molecular mechanisms in normal and cancer cells to determine new possibilities of leukemia differentiation therapy. Identification of proteins that might be involved in signaling events that mediate cancer cell differentiation. Studies of autophagy and apoptosis signaling in cancer and adult stem cell models in vitro. |
WG1 | Sascha | Martens | Austria | Vienne | University of Vienne- Max F perutz Laboratory | Reconstitution of selective autophagy. | |
WG1 | Sharon A. | Tooze | United Kingdom | London | The Francis Crick Institute | MC S | Elucidation of the molecular details of initiation and expansion of autophagosomes. Integration of the autophagic pathway with the secretory and endocytic pathways. Identification of novel regulators that control autophagy in pathological conditions. |
WG4/WG5 | Silvia | Carloni | Italy | Urbino | University Of Urbino | Role of autophagy in neurodegeneration after neonatal brain ischemia. | |
WG1/WG4 | Simona | Polo | Italy | Milan | The Firc Institute of Molecular Oncoloy | Focus on the crosstalk between autophagy and the ubiquitin. Characterization of HECW1, an E3 ligase of the Nedd4 family whose dysfunction causes impaired ubiquitination and autophagy. Interest in autophagy and in RNA metabolism, two pathways deregulated in the pathogenesis of cancer and neurodegeneration. | |
WG4 | Simone | Fulda | Germany | Frankfurt | Goethe University Frankfurt | Regulation of autophagy in cancer, therapeutic targeting of autophagy pathways. | |
WG4 | Sophie | Lotersztajn | France | Paris | INSERM | Autophagy in the control of inflammation and metabolism during chronic liver diseases (non-alcoholic and alcoholic fatty liver diseases). | |
WG2/WG4 | Sophie | Lanone | France | Créteil | INSERM | Understand the pulmonary effects of (manufactured) nanoparticles on autophagy pathway, and the role of autophagy in the biological response to (manufactured) nanoparticles. | |
WG1 | Soren | Hayrabedyan | Bulgaria | Sofia | Bulgarian Academy of Sciences | MC T | Inflammasome signalling interaction imaging and autophagy flux follow-up in Sertoli cells (http://www.nature.com/articles/srep18896) upon pro-inflammatory challenge as well as the effect of micro-RNAs (like hsa-miR-204) on autophagy modulation in prostate cancer (Wiley Molecular Carcinogenesis, 10.1002/mc.22263). |
WG5 | Stéphane | Nancey | France | Inflammatory bowel diseases, especially in dissecting the immunologic mechanisms by which gut inflamation and lesions occurred using animal models of colitis and research in humans. | |||
WG5 | Sylviane | Muller | France | Strasbourg | CNRS | TC SA | Autoimmunity, systemic autoimmune diseases, lupus. T cell and B cell epitopes, antigen-presenting cells, antibody-secreting cells, cytokines. Immunomodulation, altered peptide ligand of the T cell receptor. Autophagy, CMA, MIIC compartment, pharmacological regulators of autophagy, lysosomes. Therapeutic stratégies, mouse models of autoimmunity, autoantibodies to "some" structures. Patients, clinical trials. |
WG4 | Sylvie | Giuriato | France | Toulouse | INSERM- Cancer Research Center Toulouse | Role of autophagy in ALK positive anaplastic large cell lymphoma growth, regression and relapse. | |
WG3 | Tamar | Avin-Wittenberg | Germany | Potsdam | Max Planck Gesellschaft | Metabolic implications of autophagy during plant development and under environmental stress. | |
WG2/WG4 | Tassula | Proikas-Cezanne | Germany | Tubingen | Eberhard Karls University Tuebingen | MC T / WG2 L | WIPI-mediated autophagy in health and disease and High throughput / content assessments and screening approaches. |
WG1 | Teresa | Zoladek | Poland | Institute of Biochemistry and Biophysics PAS | Molecular genetics and cellular biology of yeast with the focus on the role of ubiquitination of proteins and functioning of the actin cytoskeleton in autophagy and endocytosis. | ||
WG4/WG5 | Teresa | Sardon | Spain | Barcelona | Anaxomics Biotech | ||
WG1 | Terje | Johansen | Norway | Tromsø | University of Tromsø - The Arctic University of Tromsø | MC S | Selective autophagy studying the autophagy receptors p62/SQSTM1 and NBR1 but also components of the basal autophagy machinery, particularly the ATG8/LC3/GABARAP family members. |
WG1/WG4 | Thierry | Arnould | Belgium | Namur | Université de Namur / University of Namur | MC S | Study of mitochondrial function and dysfunction in stem cell differentiation, metabolism, cancer and bacterial infection |
WG1 | Thierry | Soldati | Switzerland | Geneva | University of Geneva | MC T | The major aim of my group is to understand the integration, the cooperation of signalling, cytoskeleton and membrane trafficking in phagocytosis and its relevance to host-pathogen interactions. To this end, we use the social amoeba Dictyostelium as a model organism as it is a professional phagocyte very similar to mammalian phagocytes of the innate immune system in morphology and behaviour, but which is genetically and biochemically tractable (Boulais et al, 2010;Cosson & Soldati, 2008). |
Thierry | Soldati | Switzerland | Geneva | University of Geneva | MC S | ||
WG3 | Tolga | Bozkurt | United Kingdom | London | Imperial College London | My group focuses on dissecting the molecular mechanisms underlying plant cell autonomous immunity and the role of endomembrane traffic in this process. We employ plant cell biology approach to study plant-pathogen interactions. More recently, our work on effector biology shed light on how plant pathogens manipulate autophagy to enable infection. This work highlighted the extensive remodeling of endomembrane compartments during plant-microbe interactions and opened up novel perspectives in understanding the role of autophagy in plant immunity. | |
WG1 | Trond | Lamark | Norway | Tromsø | University of Tromsø - The Arctic University of Tromsø | MC S | |
WG1/WG4 | Veronika | Borutinskaite | Lithuania | Vilnius | Vilnius University | MC T | Studies of molecular mechanisms in normal and cancer cells to determine new possibilities of leukemia differentiation therapy. Identification of proteins that might be involved in signaling events that mediate cancer cell differentiation. Studies of autophagy and apoptosis signaling in cancer and adult stem cell models in vitro. |
WG1/WG2/WG3 | Viktor | Zarsky | Czech Republic | Prague | Charles University | We aim to Looking into molecular details of the relation between plant exocyst complex and autophagy. | |
WG4/WG5 | Walter | Balduini | Italy | Urbino | University Of Urbin "Carlo Bo" | MC T / TC L | Role of autophagy in neurodegeneration after toxic insult during brain development. |
WG2/WG4 | Wim | Martinet | Belgium | Antwerp | Department of Pharmaceutical Sciences | We are mainly focusing on pharmacological modulation of autophagy in cardiovascular disease (non-clinical) | |
WG5 | Ömer Nuri | Pamuk | Turkey | Edirne | Trakya University | MC T | |
WG1 | Þor (Thor) | Eysteinsson | Iceland | Reykjavik | University of Iceland | MC S | |
WG1 | Vladimir | Trajkovic | Serbia | Belgrade | University of Belgrade | MC T | Regulation and role of intracellular energy balance signalling pathways and autophagy in cancer and metabolic, neurological, and immune disorders. |
WG4 | Alexander | Pintzas | Greece | Athens | National Hellenic Research Foundation | My research interests have been in the scientific areas of Biology of Cancer and Cell Death, towards exploitation of the interplay of proliferative with apoptotic/autophagic pathways for novel cancer therapeutics and their rational combinations | |
WG4 | Giulia | Riparini | Italy | Urbania | University of Urbino Carlo Bo | Autophagy and endoplasmic reticulum stress in neurodegeneration and neuroprotection after perinatal brain damage | |
WG4 | Muriel | Priault | France | Bordeaux | Centre National de Recherche Scientifique CNRS | Autophagy, cancer, trafic, mitochondria, Bcl-xL, Rab7. | |
WG4 | Esther | Dalfó | Spain | Barcelona | Universitat Autònoma de Barcelona | Converging mechanisms between autophagy and axonal function and the metabolic influence in the regulation of neurodegenerative diseases |
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WG4 | Irena | Audzeyenka | Poland | Warsaw | Polish Academy of Sciences | Define the significance of autophagy for podocyte survival and function, as well as to assess the involvement of this process into pathogenesis of diabetic nephropathy. | |
WG4 | Ziga | Jakopin | Slovenia | Ljubljana | University of Ljubljana | MC T | Design/synthesis of ligands of pattern recognition receptors; Identification and biological evaluation of NOD1/2 receptor (ant)agonists; medicinal chemistry. |
WG4 | Vincent | Lotteau | France | Lyon | Centre International de Recherche en Infectiologie | Development of host-oriented antiviral molecules. | |
WG4 | Ana Vanessa | Oliveira | Portugal | Oeiras | Instituto de Biologia Experimental e Tecnológica and Instituto de Tecnologia Química e Biológica (ITQB/UNL) | Focused on translational science mainly biochemistry, cellular and molecular biology and its application to the field of gene therapy, development of biopolymers and diabetes. Interested in developing new disease models, including yeast models to complement tests in mammalian cells and animal models involved in the development of new therapeutical strategies. | |
WG4 | Karolina | Pircs | Sweden | Lund | Lund University | I am currently working on the linkage of autophagy and miRNAs in different neurodegenerative disorders like Huntington´s disease and Parkinson´s disease. | |
WG4 | Ioannis | Trougakos | Greece | Athens | National & Kapodistrian University of Athens | MC S | MCAC focuses on proteome stability alterations during ageing and in age‐related diseases, as well as in the discovery of natural compounds that reduce proteome aggregation and prolong proteome stability and longevity at either cell‐based and/or at in vivo experimental models. |
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