Understanding the determinants of health, improving health promotion and disease prevention. There is now solid experimental evidence that some caloric restriction mimetics (spermidine, resveratrol and other polyphenols, some of them accessible in drugstores), and exercise are new avenues to stimulate autophagy and to extend longevity. Since active aging, well-being and disease prevention are socioeconomically challenges, maximizing healthy life years might be considered a matter of healthy habits and education, such as polyphenols-rich diet and regular exercise, rather than an expensive strategy of drug development or drug consumption.

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