Working Groups


WG1

Basic Research on Autophagy Molecular Machinery 
Jon Lane

Jon Lane Leader

Patrizia Agostinis

Patrizia Agostinis Vice-Leader

WG1 aims to extend basic knowledge on Autophagy, filling the existing gaps to improve molecular understanding of the main mechanisms that regulate autophagy pathways in yeasts and higher eukaryotic cells. This Group will tackle basic research to yield fundamental insights into the autophagy pathways and to identify and validate novel targets for intervention in these pathways in different model systems. Projects are designed to characterize i) initiation and propagation machinery; ii) docking and fusion events; iii) lysosomal degradation; iv) selective autophagy; v) genetics and epigenetics; and vi) autophagy signalling and systems biology.

Objectives are:

  1. Identify molecular interactions that drive autophagosome formation and fusion and characterized the interface between autophagosomes and endocytic vesicles.
  2. Define and validate mechanisms/molecular interactions and pathways that regulate autophagic clearance of proteinaggregates, lipids, and organelles (aggrephagy, lipophagy, mitophagy, pexophagy, ER-phagy) in model systems.
  3. Define and validate the role of the autophagy-lysosomal system in sensing nutrient availability, metabolism, signalling and secretion
  4. identify gaps in the available molecular toolkit for autophagy research and develop novel tools and reagents (including CRISPR-Cas9 systems and viral-based expression vectors and derived cell-lines) through pooled expertise and resources.

This Group will provide constant methodological updates in the form of co-authored papers, forum discussions, and through the establishment of a ‘COST-autophagy-virtual lab’ where state-of-the art techniques, novel autophagy modulators, and tools developed by partners of the consortium will be disseminated.

WG1 in particular will foster the development of novel model systems and reporter cell-lines to monitor and analyse how disturbances in autophagy components affect cell viability, metabolism, cell death pathways, and the aging processes, thus providing exploitation-relevant outputs for the other WGs. In addition, WG1 will focus on development of a prototype systems models for the analysis of autophagy signalling (with WG2), which defines and predicts relevant output – physiological rebalance, survival in stress, switch to cell death – in the cellular systems explored (e.g., yeasts, plants, neurons, cancer cells). This will result in development of biomarkers for exploitation by WG4 and WG5. Since an important research gap in the field is the lack of specific modulators, WG1 will work to develop small-molecule modulators of autophagy pathways to ‘perturb’ autophagic degradation in model systems (with WG2).

 Name SurnamesCountryCityInstitutionCharge Research Line
Aleksandra IsakovicSerbiaBelgradeUniversity of BelgradeMC S
Ali KosarTurkeyIstanbulSabanci UniversityEffects of cavitation on autophagy, Flow stresses on autophagy, Bubble collapse effect.
Alicia AlonsoSpainBilbaoUniversidad del País Vasco. CSICPhospholipases and sphingomyelinases, influence of the physical state of the membrane on their enzymatic activity; ceramides, diacylglycerols; GPI-lipids; membrane fusion; lipid polymorphism.
Anders H.LundDenmarkCopenhagenUniversity of CopenhagenMC TUnveiling fundamental biological mechanisms and understand how these become perturbed during diseases, most prominently cancer, with the ambition to contribute to the development of clinical tools.
Andrea BallabioItalyPozzuoli TIGEMTo develop tools, to modulate cellular clearance and to use them to cure human diseases, including LSDs and neurodegenerative diseases such as Huntington’s, Alzheimer’s and Parkinson’s.
Anne SimonsenNorwayOsloUniversity of Oslo-Institut Of Basic Medical ScienceMC T1) Autophagy receptors and adaptors in selective autophagy, 2) Phosphoinositide-binding proteins in autophagy and 3) their role in disease.
Antonio ZorzanoSpainBarcelonaIRB Barcelona IRB Barcelona, University of Barcelona, CIBERDEMIdentification of novel modulators of autophagy and impact in complex metabolic diseases.
Aurelio SerranoSpainSevillaCSIC Instituto de Bioquímica Vegetal y FotosíntesisInterest in the interplay between lumenal acidification and autophagy. Particularly in outline which is the involvement of the different types of proton pumps (H and V-ATPases-pyrophosphatase) in this process. Additionally, interested in physiologically relevant factors affecting the activity of these pumps and how this results in inhibition or induction of autophagy and other effects at the cellular level in model organisms such as yeast, Arabidopsis thaliana, and mammalian cell lines.
Benjamin DehayFranceBordeauxIMN-CNRS UMR 5293DC LLysosomal Impairment, Parkinson's disease, Therapeutic approaches.
Carole Kretz-RemyFrance Villeurbanne Université Claude Bernard Lyon IOur group is interested in cell response to protein aggregation stresses. We have shown that upon protein aggregation stresses, NFkB transcription factor is activated and in turn induces autophagy, which participates in the clearance of protein aggregates accumulated in the cell.
Catalina Ribas Spain Madrid Universidad Autónoma de MadridOur laboratory is investigating key nodes in signalling networks involved in prevalent age-related pathologies such as metabolic/cardiovascular diseases and cancer.
Christian BehrendsGermanyFrankfurtGoethe University FrankfurtMC T / SC VL1) Role of the family of human ATG8 proteins in autophagy and beyond. 2) Crosstalk between autophagy and the ubiquitin system. 3) Embedding of autophagy within the cellular endomembrane and trafficking system. 4) Upstream regulation of autophagy (mTOR signalling).
Clarisse Berlioz-TorrentFranceParisINSERMHIV, autophagy, non-canonical role of ATG proteins, LAP, selective autophagy, restriction factor, innate immunity.
ClaudineKraftAustriaVienneUniversity of VienneSignalling and molecular steps leading to autophagosome formation.
Covadonga AlonsoSpainMadridInstituto Nacional de Invesigación y Tecnologia Agraria y AlimentariaStudying the interface between endocytosis and autophagy and its relevance in the innate immunity against viruses. It has shown that interferon-induced proteins, which can inhibit the entry by endocytosis of several viruses are expressed in amphisomes. Using a double stranded DNA virus as a model, are investigated new targets for antivirals. Also, working in biofunctionalization of nanoparticles with virus-derived sequences in collaboration with Dr. Jesus M. de la Fuente group. Studying biocompatibility and toxicity of compounds and their impact in autophagy.
Devrim GozuacikTurkeyTuzlaSabanci UniversityMC TMammalian autophagy basic mechanisms. Autophagy regulating new proteins and pathways microRNA regulation of autophagy. Role of autophagy abnormalities in diseases (cancer, neurodegenerative diseases, stroke). Manipulation of autophagy for disease treatment. Use of nano particles as autophagy drug carriers. Innovative medical device/tool development and autophagy.
Eeva-Liisa EskelinenFinlandHelsinkiUniversity of HelsinkiMC THigh-resolution 3D imaging of forming autophagosomes and role of the small GTPase RAB24 in autophagy.
Elah Pick Israel Tivon University of HaifaMC TActivation and activity of the COP9 signalosome (CSN); CRLs activity; developing CSN readout assay; NEDDylation/deneddylation; The CSN in stress, cancer and neurodegeneration. The CSN/NEDD8 axis upon oxidative stress. Regulation of sterol production and membrane fluidity by the CSN. Regulation of Autophagy by the CSN.
Elżbieta KaniaPolandWarsawKU LeuvenCalcium signaling and metabolic pathways during autophagy in cancer and neurodegenerative disorders.
Esther Dalfó Spain Barcelona Universitat Autònoma de BarcelonaConverging mechanisms between autophagy and axonal
function and the metabolic influence in the regulation of neurodegenerative
diseases"
Fabio PennaItalyTorinoUniversity of TorinoCancer cachexia, skeletal muscle, wasting, hypercabolism, mitochondria.
Florian GruberAustriaVienneMedical University of ViennaMC SThe main line of investigation is the generation, biological activities and degradation of oxidized lipids. Oxidized lipids are emerging as potent signaling mediators in the biology of aging, stress and inflammation of the skin. Oxidative stress is highly relevant to the biology of the skin as it is the organ most exposed to environmental stressors like ultraviolet light. For tath reason, the principal researh is in the interaction of oxidized lipids with the cellular stress response machineries, e.g. the Nrf2 response and autophagy.
Francesca Demarchi Italy Trieste Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (CIB)My current project aims to study the molecular intersection between autophagy, the ubiquitin-proteasome system and the calpain/calpastatin system in the context of tumor biology and in prospective of the design of novel therapeutic strategies against autophagy-dependent tumors.
Francisco WandosellSpainMadridCSIC Centro Biologiía Molecular Severo OchoaNeurodegeneration, Neuritogenesis , Neuronal morphogenesis, Alzheimer, Ischemia, Neuronal and Glial signalling.
Frank LafontFranceLilleCNRS- (UMR8204)MC S / WG2 VLHost-pathogen interaction, cellular microbiology, membrane traffic, biophysics, imaging technologies, nanotechnologies.
Fulvio Reggiori NetherlandsGroningenUniversity of Groningen, University Medical Center GroningenMC TStudy of the regulation and mechanism of autophagy using yeast as a model system. Study the role of autophagy during viral infections.
Félix M. GoniSpainBilbaoUniversidad del País VascoReconstitution of autophagosomal growth from defined components (pure human proteins and lipids); molecular interactions between autophagy-related proteins and membranes.
Gabor JuhaszHungaryBudapestEOTVOS Lorand UniversityMC TRoles and molecular mechanisms of autophagy in Drosophila.
Gabor Banhegyi Hungary Budapest Semmelweis UniversityInvestigation of the role of autophagy in the intermediary metabolism with special emphasis on glycogenolysis. Glycophagy under normal conditions and in glycogen storage diseases. Effects of autophagy modulating agents on carbohydrate metabolism.
Gian Maria FimiaItalyRomaNational institut for Infectious Diseases "Lazzaro Spallanzani" MC SRegulation of autophagy induction; Crosstalk between autophagy and the ubiquitin proteasome system; Role of autophagy in infectious diseases (HCV, HIV, MTB).
Giulia Riparini Italy Urbania University of Urbino Carlo BoAutophagy and endoplasmic reticulum stress in neurodegeneration and neuroprotection after perinatal brain damage
Giuseppe BuonocoreItalySienaUniversity of SienaRole of authophagy in the newborn.
Guillermo Velasco DíezSpainMadridMC S / WG4 LRole of autophagy in cancer, sphingolipids, autophagy-mediated cancer cell death, autophagy signalling.
Harald Wodrich France Bordeaux Université de Bordeaux"My group is interested in how viruses
overcome intrinsic immunity mechanisms during entry. In this respect we have very
nice ongoing work demonstra ng how membrane ly c adenoviruses elicit and limit
membrane damage induced selec ve autophagy. I am also a cofounder of the Club
Bordelais d'Autophagy (CAB), which is the local organizing commiFee for this years
annual French Autophagy mee ng (CFATG) in Bordeaux."
Henri BatokoBelgiumLouvain-la-NeuveUniversité catholique de LouvainMC T / WG3 LUnderstand the role, molecular mechanism and regulation of selective autophagy during abiotic stress in the plant cell.
Henrique GiraoPortugalCoimbraFaculty of Medicine University of Coimbra-IBILIMC TWorking on the molecular mechanisms involved in ubiquitin-dependent autophagy degradation of membrane proteins; cross talk endocytosis - autophagy; autophagy in heart in health and disease; autophagosome biogenesis.
Ioannis TrougakosGreeceAthensNational & Kapodistrian University of Athens,MC SMCAC focuses on proteome stability alterations during ageing and in age‐related diseases, as well as in the discovery of natural compounds that reduce proteome aggregation and prolong proteome stability and longevity at either cell‐based and/or at in vivo experimental models.
Ioannis P.Nezis UK Coventry University of WarwickMolecular mechanisms of selec6ve autophagy in health and disease
Ivan DikicGermanyFrankfurtGoethe University FrankfurtMolecular characterisation of autophagy pathway. selective autophagy receptors and adaptors.
IvanaNovak NakirCroatiaSplitSchool of Medicine, University of SplitMC T
James MurrayIrelandDublinTrinity College DublinMC T / TKC LMechanisms of autophagy regulation and control through reversible lipid and protein phosphorylation; enzymology, signalling kinases and cell ageing and ageing-related diseases.
Jan B. ParysBelgiumLeuvenDept. Cellular and Molecular Medicine & Leuven Kanker InstituutInvestigation of the role and the targets of Ca2+ intracellularly released by the endoplasmic reticulum and/or the lysosomes in the regulation of autophagy.
Jan MartinecCzech RepublicPragueThe Czech Academy of SciencesMC TFocused to unravelling of molecular mechanism of lipids and lipid-metabolizing enzymes involvement in plant autophagy induced by stress conditions
Jason KingUnited KingdomSheffieldUniversity of SheffieldUnderstanding molecular mechanisms of autophagy, and its regulation.
Jelena StankovicSerbiaBelgradeUniversity of BelgradeTesting new compounds, their anti-proliferative capacity and mechanisms involved in this process
Jerome JoubèsFranceVillenave d'OrnonUniversité Bordeaux SegalenIdentification of the lipids associated with autophagy and characterization of the molecular mechanisms controlling their mobilization and their functions in plant stress responses.
Joanna KamińskaPolandWarsawInstitute of Biochemistry and Biophysics PASMC S
Joern DengjelGermanyFreiburgUniversity of FreiburgAutophagosome, signaling, proteomics, protein turnover, mitophagy.
Jon LaneUnited KingdomBristolUniversity of BristolMC T / WG1 LMolecular regulation of autophagosome assembly; ATG4 proteins; erythropoiesis; neurodegeneration; iPSC.
Jordi Alcaraz Spain Barcelona Universitat de BarcelonaStudying the role of tumor associated fibroblasts (TAFS) in lung cancer progression
José A. Sánchez AlcázarSpainSevillaUniversidad Pablo de OlavideMitophagy
José M.Jerez AragonésSpainMálagaUniversidad de MálagaDetecting autophagy prognostic signature in cancer.
José-Luis CrespoSpainSevillaCSICRedox regulation of autophagy by stress and chloroplast damage in photosynthetic eukaryotes using the unicellular green alga Chlamydomonas reinhardtii as model system.
Krassimira Todorova-HayrabedyanBulgariaSofiaBulgarian Academy of SciencesMC SEffect of micro-RNAs (hsa-miR-204) on autophagy modulation in prostate cancer
Lenka GemperlováCzech RepublicPragueInstitute of Experimental BotanyMC SThe first area concerns plant developmental processes studied especially on the system of coniferous somatic embryogenesis. Since autophagy is an integral part of the suspensor cell death in plant embryogenesis, we plan to study in details the early somatic embryo development phase in gymnosperms. The second part includes the effect of polyamines on the cell growth, plant cell cycle and plant responses to abiotic stresses
Leopold Eckhart AustriaViennaMedical University of ViennaMC TAutophagy in epithelial cells.
Lisa Frankel Denmark Brønshøj University of CopenhagenInterconnection between RNA and autophagy. In particular, working with RNA binding proteins that impact on the autophagy signalling pathway.
Lucie Fischerová Czech RepublicPragueInstitute of Experimental BotanyMolecular characterization of plant polyamine metabolism. The connection of polyamines and autophagy studied in the model system of coniferous somatic embryogenesis.
Ludwig Eichinger Germany Köln University of Cologne"Our main research interest is the analysis of the molecular mechanism of autophagy in
D. discoideum. In particular, we are interested in the link between autophagy and the
proteasome, the role of autophagy in host-pathogen interactions and in non-autophagic
functions of core autophagy proteins."
Margret OgmundsdottirIcelandReykjavikUniversity of IcelandMC T
Maria Cristina AlbertiniItalyUrbinoUniversity Of Urbino "Carlo Bo"MicroRNAs involved in the epigenetic regulation of autophagy.
María SoengasSpainMadridSpanish National Research CentreWG5 SAMolecular basis of melanoma progression and response to therapy.
Nadine CamougrandFranceBordeaux cedexInstitut de Biochimie et Génétique CellulairesStudy of mitophagy in the yeast Saccharomyces cerevisiae.
Nektarios TavernarakisGreeceHeraklionFoundation for Research nd Technology-HellasMC TAgeing, Cell Death, Mitophagy, Neurodegeneration, Pexophagy, Stress Responses.
Nicholas KtistakisUnited KingdomCambridgeBabraham InstitutMechanisms of autophagy induction; signaling during autophagy; discovery of small molecules regulating autophagy.
Patrice CodognoFranceParisINSERMMC T / Vice ChairMembrane dynamics of autophagosomal compartment. Interplay between autophagy and the primary cilium: role in mechanical stress integration. Role of autophagy in self-renewal of cancer stem cells and their targeting in breast cancer treatment.
Patrizia AgostinisBelgiumLeuvenUniversity of Leuven/KU LeuvenMC T / WG1 VLMelanomagenesis, angiogenesis, lymphangiogenesis, crosstalk cancer cell-stromal cells, mitophagy and metabolism, role of cancer cell-associated autophagy in therapy resistance, role of autophagy in immunogenic cell death and release of cytokines/chemokines.
Radostina Alexandrova BulgariaSofiaMuseum-Bulgarian Academy of Sciences (IEMPAM-BAS)MC TWorking in the field of experimental oncology and oncopharmacology. Establishment and morphological and functional characterization of model systems (primary cultures and permanent cell lines, including drug resistant cell lines), evaluation of antitumor activity of synthetic compounds and natural products and attempts to identify their molecular/cellular targets and mechanisms of action
Raphaël RodriguezFranceParisInstitut CurieIdentify small molecule regulators of autophagy.
Regina MenezesPortugalOeirasEstação Agronómica Nacional - Edificio iBET/ITQBMC SInterests focused on translational science mainly (1) the dissection of the molecular mechanisms underlying Islet Amyloid PolyPeptide (IAPP) cytotoxicity in DIABETES MELLITUS – type 1 and 2 as well as pancreas transplantations – and (2) the identification/deep characterization of PROTECTIVE PHYTOCHEMICALS. For that, investing huge efforts in the development of amenable disease models aiming at exploitation of new therapeutic strategies
Renaud LegouisFranceSaclayCNRSUnderstand the physiological roles of autophagy in C. elegans life cycle (development and aging). Analyse the specific roles of LC3 family in autophagy mechanisms.
Ricardo EscalanteSpainMadridCSICMechanisms of autophagy. Origin of autophagosomes. Functional and comparative Genomics using Dictyostelium discoideum and Mammalian cells as model systems in pathology to identify and characterize novel genes involved in autophagy. Function of VPS13 proteins and their role in Chorea-acanthocytosis and autophagy.
Rune MatthiesenPortugalLisboaInstitut Nacional de Saude Dr Ricardo Jorge (INSA,I.P.)Interested in exploring the use of state of art mass spectrometry in combination with transfected cell lines to study drug induced autophagy in relation to drug resistance.
Rüta NavakauskienèLithuaniaVilniusVilnius UniversityMC SStudies of molecular mechanisms in normal and cancer cells to determine new possibilities of leukemia differentiation therapy. Identification of proteins that might be involved in signaling events that mediate cancer cell differentiation. Studies of autophagy and apoptosis signaling in cancer and adult stem cell models in vitro.
Sascha MartensAustriaVienneUniversity of Vienne- Max F perutz LaboratoryReconstitution of selective autophagy.
Sharon A. ToozeUnited KingdomLondonThe Francis Crick InstituteMC SElucidation of the molecular details of initiation and expansion of autophagosomes. Integration of the autophagic pathway with the secretory and endocytic pathways. Identification of novel regulators that control autophagy in pathological conditions.
Simona PoloItalyMilanThe Firc Institute of Molecular OncoloyFocus on the crosstalk between autophagy and the ubiquitin. Characterization of HECW1, an E3 ligase of the Nedd4 family whose dysfunction causes impaired ubiquitination and autophagy. Interest in autophagy and in RNA metabolism, two pathways deregulated in the pathogenesis of cancer and neurodegeneration.
SorenHayrabedyanBulgariaSofiaBulgarian Academy of SciencesMC TInflammasome signalling interaction imaging and autophagy flux follow-up in Sertoli cells (http://www.nature.com/articles/srep18896) upon pro-inflammatory challenge as well as the effect of micro-RNAs (like hsa-miR-204) on autophagy modulation in prostate cancer (Wiley Molecular Carcinogenesis, 10.1002/mc.22263).
TeresaZoladekPolandInstitute of Biochemistry and Biophysics PASMolecular genetics and cellular biology of yeast with the focus on the role of ubiquitination of proteins and functioning of the actin cytoskeleton in autophagy and endocytosis.
Terje JohansenNorwayTromsøUniversity of Tromsø - The Arctic University of TromsøMC SSelective autophagy studying the autophagy receptors p62/SQSTM1 and NBR1 but also components of the basal autophagy machinery, particularly the ATG8/LC3/GABARAP family members.
Thierry ArnouldBelgiumNamurUniversité de Namur / University of NamurMC SStudy of mitochondrial function and dysfunction in stem cell differentiation, metabolism, cancer and bacterial infection
Thierry Soldati Switzerland Geneva University of Geneva MC TThe major aim of my group is to understand the integration, the cooperation of signalling, cytoskeleton and membrane trafficking in phagocytosis and its relevance to host-pathogen interactions. To this end, we use the social amoeba Dictyostelium as a model organism as it is a professional phagocyte very similar to mammalian phagocytes of the innate immune system in morphology and behaviour, but which is genetically and biochemically tractable (Boulais et al, 2010;Cosson & Soldati, 2008).
Trond LamarkNorwayTromsøUniversity of Tromsø - The Arctic University of TromsøMC S
Veronika BorutinskaiteLithuaniaVilniusVilnius UniversityMC TStudies of molecular mechanisms in normal and cancer cells to determine new possibilities of leukemia differentiation therapy. Identification of proteins that might be involved in signaling events that mediate cancer cell differentiation. Studies of autophagy and apoptosis signaling in cancer and adult stem cell models in vitro.
Viktor ZarskyCzech RepublicPragueCharles UniversityWe aim to Looking into molecular details of the relation between plant exocyst complex and autophagy.
Viktor KorolchukUnited KingdomNewcastleNewcastle UniversityWorking on molecular mechanisms of mTOR and autophagy regulation and their relevance to neurodegeneration and cancer.
Zoltán GáspáriHungaryBudapestPazmany Peter Catholic UniversityMC TExplore the structure - dynamics - function relationships in proteins & protein complexes involved in autophagy. Identification of structural motifs in autophagy-rlated proteins. Evolution of the protein network involved in autophagy and its connection with other biological processes.
Þor (Thor)EysteinssonIcelandReykjavikUniversity of IcelandMC S
Vladimir Trajkovic Serbia Belgrade University of BelgradeMC TRegulation and role of intracellular energy balance signalling pathways and autophagy in cancer and metabolic, neurological, and immune disorders.

WG2

Strategies for Autophagy analyses and modulation
Tassula Proikas-Cezanne

Tassula Proikas-Cezanne Leader

Frank Lafont

Frank Lafont Vice-Leader

To enable translation of Autophagy research from bench to bedside, WG2 will focus on development of: i) tool kits for Autophagy analyses; ii) platforms for drug discovery; iii) nanotechnology; and iv) synthetic biology engineering for autophagy modulation.

In particular, objectives are:

  1. Advance and optimize high-throughput platforms that assess autophagy to enable therapy-relevant drug discovery.
  2. Improve and develop nanodetection, nanocharacterization, and nanodevices to establish nanomaterial-autophagy interactions.
  3. Utilize systems biology to predict areas of translational applications for novel drugs and nanomaterials targeting autophagy in age-related human diseases.
  4. Develop foundational understanding to design rational synthetic biology solutions for translational autophagy modulation in both prevention and therapy of age-related human diseases
  5. Establish standardized methods to collect and facilitate integrative analysis of Big Data from ‘omics and systems and population biology experiments in the context of stratification of personalized medicine and wellbeing.

WG2 will foster Autophagy assay improvement and development suitable for large scale quantifications in ‘omics, imaging, and systems biology (together with WG3 and WG5), and technical improvement of automated platform performances to score for autophagy in drug/nanomaterial discovery screening as well as diagnostic-clinical approaches (together with WG3 and WG5). In addition, WG2 will establish two open access databases: One will collect data and experimental procedures that monitor the process of autophagy in cells and organisms and to formulate a detailed repertoire of evidence-based guidelines on autophagy testing, validation, and quantification in biological assays (together with the other Working Groups). The other will be an open-access largescale data mining and prediction pipeline for autophagy-based systems biology approaches in wellbeing and diseases that will include mathematical modelling algorithms for the development of nanoenabled synthetic biology solutions against chronic, infectious, cancer, and neurological diseases (together with WG1 and WG4).

 Name SurnamesCountryCityInstitutionCharge Research Line
Antonio ZorzanoSpainBarcelonaIRB Barcelona IRB Barcelona, University of Barcelona, CIBERDEMIdentification of novel modulators of autophagy and impact in complex metabolic diseases.
Antonio CuadradoSpainMadridUniversidad Autónoma de MadridProteostasis alterations of Alzheimer and Parkinson’s disease and the possibility to use autophagy as a therapeutic target.
Benjamin DehayFranceBordeauxIMN-CNRS UMR 5293DC LLysosomal Impairment, Parkinson's disease, Therapeutic approaches.
Clara MarquinaSpainZaragozaCSIC-Universidad de ZaragozaNanotechnology & Autophagy: Influence of different types of nanomaterials (nanoparticles etc) on inducing autophagy. Characterization by nanotechnology tools (Dual Beam 3 Nova 200, advanced TEM techniques etc.) of cells after induced autophagy. Magnetic hyperthermia as trigger mechanism of autophagy.
Daniel HofiusSwedenUppsalaSwedish University of Agricultural Sciences (SLU)Plant-pathogen interactions, innate immunity; programmed cell death; host and pathogen targets of selective autophagy; viral pathogenesis and antiviral immunity; membrane trafficking; steroid signalling; epigenetic regulation; crosstalk with proteasome, stress and pathogen resistance in crop plants, plant biotechnology, translational and cross-kingdom approaches.
Fernando Novio VázquezSpainBarcelonaCSIC Institut Català de Nanociència i nanotecnologiaDesign, synthesis and characterization of nanoconstrucs as nanocontainers for different drugs and active species. Interest in the modulation of macroautophagy-lysosomal system (MALS) disorders for the treating of different diseases using nanoparticles.
Florian GruberAustriaVienneMedical University of ViennaMC SThe main line of investigation is the generation, biological activities and degradation of oxidized lipids. Oxidized lipids are emerging as potent signaling mediators in the biology of aging, stress and inflammation of the skin. Oxidative stress is highly relevant to the biology of the skin as it is the organ most exposed to environmental stressors like ultraviolet light. For tath reason, the principal researh is in the interaction of oxidized lipids with the cellular stress response machineries, e.g. the Nrf2 response and autophagy.
Frank LafontFranceLilleCNRS- (UMR8204)MC S / WG2 VLHost-pathogen interaction, cellular microbiology, membrane traffic, biophysics, imaging technologies, nanotechnologies.
Giuseppe MaulucciItalyRomaUniversità Cattolica del Sacro CuoreWorking in the field of functional imaging, on the relationship between redox state and the physical state of biomembranes mediated by lipid peroxidation products. Recently developedment of a method of confocal analysis that allow the quantification of the autophagic flux.
Guillermo Velasco DíezSpainMadridMC S / WG4 LRole of autophagy in cancer, sphingolipids, autophagy-mediated cancer cell death, autophagy signalling.
Ioannis TrougakosGreeceAthensNational & Kapodistrian University of Athens,MC SMCAC focuses on proteome stability alterations during ageing and in age‐related diseases, as well as in the discovery of natural compounds that reduce proteome aggregation and prolong proteome stability and longevity at either cell‐based and/or at in vivo experimental models.
Jesús M de la FuenteSpainZaragozaCSIC Instituto de Ciencia de Materiales de AragónMC T / TKC VLStudy of nanoparticle-cell interactions, study of endocytosis mechanisms, photothermal Therapy, Magnetic Hyperthermia. Funcionalización de superficies para el desarrollo de procesos de adhesión celular y reconocimiento molecular, y por otro lado, la preparación, caracterización y biofuncionalización de nanopartículas metálicas para su empleo en biosensores y terapia tumoral. La modificación química de la superficie de las nanopartículas o de las diferentes superficies, así como la modificación de las proteínas o carbohidratos a unir es un requisito indispensable para una biofuncionalización adecuada de estos materiales para su uso en el desarrollo de nanobiosensores. A pesar de tener una amplia experiencia en la preparación de estos materiales, es en el ámbito de su funcionalización con moléculas de interés biológico (enzimas, anticuerpos, sondas de ADN, etc) donde se centra nuestra investigación.
José-María Sánchez-PuellesSpainMadridCSICTarget validation for drug discovery, autophagy & aging.
M. Ricardo Ibarra GarcíaSpainZaragozaUniversidad de ZaragozaInfluence of different types of nanomaterials (nanoparticles etc) on inducing autophagy. Characterization by nanotechnology tools (Dual Beam 3 Nova 200, advanced TEM techniques etc.) of cells after induced autophagy. Magnetic hyperthermia as trigger mechanism of autophagy.
Marta Martínez-VicenteSpainBarcelonaVall d'Hebron Institut de RecercaMC SNeurodegeneration, Parkinson, Huntington, therapy, nanotechnology.
Mattia MoriItalyRomaIstituto Italiano di Tecnologia [Center for Life Nano Science]MC TDesign/optimization of small molecules; drug discovery; computational structural studies on target proteins; in silico mutagenesis; computational folding studies; natural products; medicinal chemistry.
Monika CahovaCzech RepublicPragueInsititut For Clinical and Experiental Medicine1) the evolution of mitochondrial changes in pancreatic β-cells in different experimental models of type-2 diabetes, with respect to the alterations in mitophagy. 2) the role of (dys)regulation of autophagy in the development of type-2 diabetes-related metabolic disorders, particularly liver steatosis.
Nektarios TavernarakisGreeceHeraklionFoundation for Research nd Technology-HellasMC T Ageing, Cell Death, Mitophagy, Neurodegeneration, Pexophagy, Stress Responses.
Raphaël RodriguezFranceParisInstitut CurieIdentify small molecule regulators of autophagy.
Sophie LanoneFranceCréteilINSERMUnderstand the pulmonary effects of (manufactured) nanoparticles on autophagy pathway, and the role of autophagy in the biological response to (manufactured) nanoparticles.
Tassula Proikas-CezanneGermanyTubingenEberhard Karls University TuebingenMC T / WG2 LWIPI-mediated autophagy in health and disease and High throughput / content assessments and screening approaches.
Viktor ZarskyCzech RepublicPragueCharles UniversityWe aim to Looking into molecular details of the relation between plant exocyst complex and autophagy.
Alexander Pintzas GreeceAthens National Hellenic Research Foundation “My research interests have been in the scientific areas of Biology of Cancer and Cell Death, towards exploitation of the interplay of proliferative with apoptotic/autophagic pathways for novel cancer therapeutics and their rational combinations”.
Ana Vanessa Oliveira Portugal Oeiras Instituto de Biologia Experimental e Tecnológica and Instituto de Tecnologia Química e Biológica (ITQB/UNL) Focused on translational science mainly biochemistry, cellular and molecular biology and its application to the field of gene therapy, development of biopolymers and diabetes. Interested in developing new disease models, including yeast models to complement tests in mammalian cells and animal models involved in the development of new therapeutical strategies.
Catalina Ribas Spain Madrid Universidad Autónoma de MadridOur laboratory is investigating key nodes in signalling networks involved in prevalent age-related pathologies such as metabolic/cardiovascular diseases and cancer.
Jordi Alcaraz SpainBarcelona Universitat de BarcelonaStudying the role of tumor associated fibroblasts (TAFS) in lung cancer progression
Nikolai Engedal Norway Oslo University of Oslo MC T / TKC VL1) Regulation of autophagy by calcium perturbation and ER stress signaling/ the unfolded protein response 2) Intersections between autophagy and apoptosis 3) Specific roles and mechanisms of action of mammalian Atg8 proteins in autophagy
Wim Martinet Belgium Antwerp Department of Pharmaceutical Sciences We are mainly focusing on pharmacological modulation of autophagy in cardiovascular disease (non-clinical)

WG3

Autophagy Applied to Crop and Energy production
Henri Batoko

Henri Batoko Leader

Agnieszka Sirko

Agnieszka Sirko Vice-Leader

WG3 aims to extend current knowledge on autophagy in phototrophic organisms, identifying critical gaps in knowledge and translating this knowledge into enhancing plant growth, optimizing nutrient utilization, improving food quality, and modulating stress responses and immunity. WG3 will analyse: i) Autophagy in plant immune responses; ii) Autophagy in abiotic stress responses; and iii) Autophagy in plant development.

Specific objectives are:

  1. Collect, evaluate, and categorize (in collaboration with WG1 and WG2) the available data on the molecular mechanisms that activate the ‘core autophagy’ machinery and programmed cell death in various stages of plant development – from seed-to-seed, with emphasis on plant-specific role of ATG proteins in seed germination, plant growth, and development under adverse conditions, immunity responses, and qualitative and quantitative nutrient mobilization.
  2. Compare and evaluate (in collaboration with WG1 and WG2) current methods, including pharmacological approaches, for assessing, modulating, and quantifying autophagy in phototrophic organisms, a system posing unique challenges compared to mammalian and yeast systems.
  3. Establish a framework for the development of new techniques to monitor autophagy in photosynthetic organisms and to understand how this pathway intersects with other degradation systems (vacuolar and non-vacuolar) and vesicular processes in photosynthetic organisms (in collaboration with WG1 and WG2).
  4. Develop a forum among specialists of different disciplines to better understand the role of autophagy and mechanisms that regulate autophagy at the tissue, cellular, and subcellular levels (in collaboration with WG2).
  5. Encourage excellent collaborative work toward the identification of exogenous and endogenous factors that induce and regulate selective autophagy in plants with emphasis on the signalling networks and the selective cargo receptors involved and their cognate targets.

 Name SurnamesCountryCityInstitutionCharge Research Line
Agnieszka SirkoPolandWarsawInstitut Of Biochemistry and Biophysics PolishMCT / WG3 VLAbiotic stress, Starvation, Nutrient deficit, Protein-protein interactions, Molecular biology, Ubiquitination.
Alisdair FernieGermanyGolmMax Planck GesellschaftAutophagy's role in plant metabolism.
Anna WawrzyńskaPolandWarsawInstitute of Biochemistry and BiophysicsMC S
Béatrice Satiat-Jeunemaitre FranceGif sur YvetteInstitut de Biologie Intégrative de la Cellule - CNRSPlant cell biology, Morphodynamics of cell comparment, autophagosome, Endomembranes.
Cecilia GotorSpainSevillaCSIC Institut de Bioquímica Vegetal y FotosíntesisArabidopsis, Cysteine, Sulfide, Plant Stress, Proteomic.
Céline Masclaux-Daubresse FranceVersaillesInstitut National de recherche AgronomiqueAbiotic stress (N, S limitations), Nutrient recycling, Nitrogen remobilisation, Leaf senescence, Metabolism, 15N tracing.
Daniel HofiusSwedenUppsalaSwedish University of Agricultural Sciences (SLU)Plant-pathogen interactions, innate immunity; programmed cell death; host and pathogen targets of selective autophagy; viral pathogenesis and antiviral immunity; membrane trafficking; steroid signalling; epigenetic regulation; crosstalk with proteasome, stress and pathogen resistance in crop plants, plant biotechnology, translational and cross-kingdom approaches.
Erika IsonoGermanyFreisingTechnische Universität MünichIntracellular trafficking, endocytosis, Autophagy, Biochemistry, Cell biology.
Fernanda Suárez MarínSpainMálagaUniversidad de MálagaProgrammed cell death, autophagy, metacaspase, plant embryo development.
Francisca SevillaSpainMurciaCSIC Centro de Edafología y Biología Aplicada del Segura Arabidopsis, Pisum, redox proteins, mitochondria, proteomic, Plant stress, developement.
Frantisek BaluskaGermanyBonnUniversity of Bonn- IZMBCytoskeleton, Signaling, Endocytosis, Myotubularins, Root Cells, Imaging.
Henri BatokoBelgiumLouvain-la-NeuveUniversité catholique de LouvainMC T / WG3 LUnderstand the role, molecular mechanism and regulation of selective autophagy during abiotic stress in the plant cell.
Jerome JoubèsFranceVillenave d'OrnonUniversité Bordeaux SegalenIdentification of the lipids associated with autophagy and characterization of the molecular mechanisms controlling their mobilization and their functions in plant stress responses.
Luisa M. SandalioSpainGranadaConsejo Superior de Investigaciones cientificas. Estación Esperimental del ZaidinPeroxisomes, biotic and abiotic stress, imaging, reactice oxygen and nitrogen species.
M. Gonzalo Claros DíazSpainMálagaUniversidad de MálagaDetemine which biomarkers and genes are involved, and how are involved, in autophagy.
Michele Wolf BianchiFranceLyonCNRSAutophagosome Formation, Imaging, Abiotic Stress.
Morten PetersenDenmarkCopenhagenCopenhagen University- Faculty of scienceMC SInnate immunity, autophagy, MAP kinase signaling, development,
Núria Sánchez Coll SpainBarcelonaCenter for research in agricultural GenomicsBiotic stress, Programmed cell death.
Peter BozhkovSwedenUppsalaSwedish University of Agricultural Sciences (SLU)Aging, Plant development, Programmed cell death, Catabolism.
Pilar S. TestillanoSpainMadridBiological Research Center (CIB), Spanish National Research Council (CSIC)Autophagy in plant development, abiotic stress, plant programmed cell death, bioimaging, cell biology.
Tamar Avin-WittenbergGermanyPotsdamMax Planck GesellschaftMetabolic implications of autophagy during plant development and under environmental stress.
Viktor ZarskyCzech RepublicPragueCharles UniversityWe aim to Looking into molecular details of the relation between plant exocyst complex and autophagy.
Antia Rodriguez-VillalonSwitzerland Zurich ETH-ZurichVascular development study in which autophagy has a key role, in particupar in "postmortem" stages.
Hadas Zehavi Israel Rehovot Weizzmann Institute of Science "My work is mainly focused on a plant-specific ATG8-binding
cargo receptor (ATI1) that is induced under stress and involved in the recycling of
chloroplast proteins and possibly in ER to vacuole trafficking. ATI1 represents an interes ng
path of autophagy, as it is ini ally associated with vesicles that defer from classic
autophagosomes, but clearly requires ATG8 and the autophagic machinery to get to the
vacuole. We are aiming to elucidate its physiological role under normal growth condi ons
and under stress, as well as its rela on to the autophagy machinery and its trafficking to
the vacuole."
Tolga Bozkurt United KingdomLondonImperial College LondonMy group focuses on dissecting the molecular mechanisms underlying plant cell autonomous immunity and the role of endomembrane traffic in this process. We employ plant cell biology approach to study plant-pathogen interactions. More recently, our work on effector biology shed light on how plant pathogens manipulate autophagy to enable infection. This work highlighted the extensive remodeling of endomembrane compartments during plant-microbe interactions and opened up novel perspectives in understanding the role of autophagy in plant immunity. 

WG4

Biomedical Research
Guillermo Velasco Díez Chair

Guillermo Velasco Díez Chair Leader

Mario Tschan

Mario Tschan Vice-Leader

Nadezda Apostolova

Nadezda Apostolova Scientific Advisor

WG4 will integrate what is known about Autophagy in: i) physiology and aging; ii) particular organ dysfunctions; iii) metabolic disorders; iv) cancer; v) immunity, inflammatory diseases, and infectious diseases, and vi) drug-induced toxicity. This group will generate ideas that have the potential to be translated into novel clinical and biotechnological applications by using the basic knowledge obtained by the different WGs. The focus of WG4 is to identify functions and dysfunctions of autophagy in cellular and animal models of human diseases and use this knowledge to: i) identify (autophagy-related) biomarkers of disease and ii) design therapeutic strategies based on the manipulation of autophagy. The ultimate objective of WG4 is to provide – based on results obtained in preclinical models of disease – the basis for the development of novel biomedical applications.

Specific tasks are:

  1. Determine the molecular mechanisms by which autophagy regulates the pathogenesis of different diseases.
  2. Understand the interplay between autophagy and cell death in different diseases.
  3. Investigate and elucidate the effect of autophagy modulation (using different approaches) in preclinical models of disease.
  4. Investigate the mechanisms by which currently approved drugs modify autophagy in different cell types and assess the clinical implications of such interference.

 Name SurnamesCountryCityInstitutionCharge Research Line
IvanaNovak NakirCroatiaSplitSchool of Medicine, University of SplitMC T
Eva ZerovnikSloveniaLjubljanaInstitut Jozef StefanMC TTo get to know the molecular basis of neurodegenerative diseases, our lab is interested in cellular consequences of protein aggregation, such as recruitment of chaperones and autophagy. We concentrate on stefin B from the family of cystatins. Other processes of interest are aggresome formation, lysosomal and mitochondrial pathways of cell death and innate immune response.
Jelena DinicSerbiaBelgradeInstitute for Biological Research "Sinisa Stankovic"MC TTargeting multidrug resistance (MDR) in cancer, mainly the evaluation of new autophagy modulators and inhibitors of P-glycoprotein function as anticancer drug candidates. Special attention is given to autophagy as one of the mechanisms of MDR, and the potential solutions for overcoming of this phenomenon. We utilize MDR human and animal cell lines as models for studying the anticancer effects and the mechanisms of action in wide range of new natural, synthetic and semi-synthetic agents.
Christine ConnollyIrelandDublinCentre for bionano interactions
DanielRuiz-MolinaSpainBarcelonaCSIC Institut Català de Nanociència i Nanotecnologia
Frank Lezoualc'hFranceToulouseINSERMTo study new signaling pathways induced by adrenergic stimulation and involved in Aging and the development of Heart Failure. Our major goal is to better understand how those signaling pathways (i.e cAMP-Epac, monoamine oxidase-A) interfere with autophagy to regulate cardiomyocyte fate (cell death, hypertrophy, senescence) in the heart. By improving autophagy, we aim at counteracting the deleterious mechanisms associated with cardiac dysfunction such as cardiomyocyte death and mitochondrial damage
Filippo BertoliIrelandDublinCBNI, University College Dublin
Anne SimonsenNorwayOsloUniversity of Oslo-Institut Of Basic Medical ScienceMC T1) Autophagy receptors and adaptors in selective autophagy, 2) Phosphoinositide-binding proteins in autophagy and 3) their role in disease.
Florence PinetFranceLilleINSERMMC S1) Cardiovascular diseases, mainly heart failure. 2) Mechanisms of autophagy in link with our proteomic data sets obtained from human cohorts of patients and experimental animal models of heart fialure. 3) Translational research with availility oh human samples dedicated to our reaserch project. 4) Close link with clinicians (cardiologists, vascular surgeons)
Nektarios TavernarakisGreeceHeraklionFoundation for Research nd Technology-HellasMC T Ageing, Cell Death, Mitophagy, Neurodegeneration, Pexophagy, Stress Responses.
Christophe ViretFranceLyonINSERMAU-utophagy in infection and Crohn
José M.FuentesSpainCáceresUniversidad de ExtremaduraAutophagy and Parkinson's disease. Role of PARK genes and environmental factors.
Iraide AllozaSpainBilbaoUniversidad del País Vasco Autophagy Biomarkers in Aterosclerosis
Martine Biard-PiechaczykFranceMontpellierCentre d’études d’agents Pathogènes et Biotechnologies pour la SantéAutophagy during viral infections, mainly HIV-1 infection. The aim is to better understand the interactions between HIV-1 and autophagy in critical immune cells of the host in order to open new avenues for therapeutic and prophylactic strategies.
Mario CorderoSpainSevillaUniversidad de SevillaAutophagy in aging and rare diseases.
Aurore RozièresFranceLyonCSIC-Univ. de Sevilla, Instituto de Bioquímica Vegetal y FotosíntesisAutophagy in Crohn's disease
Leopold Eckhart AustriaViennaMedical University of ViennaMC TAutophagy in epithelial cells.
María Luz Martínez ChantarSpainDerioCIC bioGUNEAutophagy in fatty liver disease.
Miguel Antonio López PérezSpainSantiago de CompostelaUniversidad Santiago de CompostelaAutophagy in hippotalamus control of obesity and metabolism.
Nicolas PalletFranceBordeaux INSERMAutophagy in kidney disease; autophagy in renal stress response; autophagy and endoplasmic reticulum stress
Sophie LotersztajnFranceParisINSERMAutophagy in the control of inflammation and metabolism during chronic liver diseases (non-alcoholic and alcoholic fatty liver diseases).
Mograbi BahariaFranceNiceInstitut National de la sante et de la recherche médicale INSERM- IRCANAutophagy process at molecular, cellular and integrative levels in order to delineate (i) the link between autophagy, ageing and chronic diseases, (ii) the susceptibility to intrinsic (epigenetic) and extrinsic (nutrition, pollutants, carcinogens) factors and (iii) first-in-class therapies that will improve healthy ageing, slow and prevent ageing diseases (specifically cancer).
Nadezda ApostolovaSpainValencia Universitat de ValenciaWG4 SAAutophagy related to HIV infection and antiretroviral drugs.
Priault MurielFranceBordeauxCentre National de Recherche Scientifique CNRSAutophagy, cancer, trafic, mitochondria, Bcl-xL, Rab7.
David RubinszteinUnited KingdomCambridgeUniversity of CambridgeBasic autophagy biology, Drug discovery, Translation.
DiegoRuano CaballeroSpainSevillaUniversidad de SevillaBasic mechanisms. Age-related modifications. Role on neurodegeneration and cancer. Cross-talk Autophagy/Proteasomal suystem. ER-stress-UPR-Autophagy.
Julia LorenzoSpainBarcelonaUniversitat Autònoma de BarcelonaBioengineering
Elżbieta KaniaPolandWarsawKU LeuvenCalcium signaling and metabolic pathways during autophagy in cancer and neurodegenerative disorders.
Fabio PennaItalyTorinoUniversity of TorinoCancer cachexia, skeletal muscle, wasting, hypercabolism, mitochondria.
Mario P.TschanSwitzerlandBernUniversity of BernMC TCell Differentiation, physiology an dynamics.
Leonidas StefanisGreeceAthensBiomedical Research Fondation Of the Academy of AthensMC TDeciphering the involvement of autophagic pathways in neurodegenerative diseases, in particular Parkinson's Disease and related synucleinopathies; using this knowledge to devise novel therapeutic strategies based on modulation of autophagy, and in particular Chaperone-Mediated Autophagy (CMA).
Mojgan Djavaheri-MergnyFranceBordeauxINSERM- INSERM U916Deciphering the role of autophagy in cancer cells.
Marco SandriItalyPadovaUniversity Of Padova-Venetian Institut of Molecular MedicineDefining the role of autophagy in acquired and inherited cardiac and skeletal muscle diseases.
José M.García FernándezSpainCartujaCSIC Instituto de Investigaciones QuímicasDesign of molecules interfering with lysosomal glycosidases involved in metabolic disorders implying autophagy deregulation. Development of pharmacological chaperones and nanodevices for the treatment of lysosomal storage disorders (Gaucher, Fabry, GM1 gangliosidosis, Tay-Sachs). Effect of pharmacological chaperones in autophagy and implementation of chaperone therapies and combined therapies.
Patrice AndréFranceLyonCentre International de Recherche en InfectiologieDevelopment of host-oriented antiviral molecules.
José M.LizcanoSpainBarcelonaUniversitat Autònoma de BarcelonaDissection of new signaling pathways in cancer and developing new antitumor drugs.
Marcello PintiItalyModenaUniversita Di Modena e Reggio EmiliaEffects of antiretroviral drugs used in HIV treatment on autophagy and mitophagy, particularly in adipocytes.
Caty CasasSpainBarcelonaUniversitat Autònoma de BarcelonaChairEndogenous mechanisms in retrograde motoneurodegeneration and axonal damage.
Chantal M.BoulangerFranceParisINSERMEndothelial autophagy, senescence, cardiovascular diseases, inflammation, apoptosis, atherosclerosis, endothelial shear stress, endothelial function.
Cécile VindisFranceToulouseINSERMMC TExploring the role of mitophagy in atherosclerosis as a new target for plaque stabilization.
Simona PoloItalyMilanThe Firc Institute of Molecular OncoloyFocus on the crosstalk between autophagy and the ubiquitin. Characterization of HECW1, an E3 ligase of the Nedd4 family whose dysfunction causes impaired ubiquitination and autophagy. Interest in autophagy and in RNA metabolism, two pathways deregulated in the pathogenesis of cancer and neurodegeneration.
Mathias FaureFranceLyonINSERM, CNRS - Université Lyon MC S / WG4 VLFunction and regulation of autophagy in infections and immunity.
Markus RehmGermanyStuttgartUniversity of StuttgartFunctional, mechanistic and kinetic understanding at the level of signaling systems; Identification of combinatorial systems biomarkers and development of innovative stratification tools.
Rafael Delgado VázquezSpainMadridInstitut de Investigación Hospital 12 de OctubreHIV and Ebola models.
Arnaud MorisFranceParisCenter for Immunology and Microbial infections - ParisHost-Pathogen interactions, Adaptive Immunity, Inflammation, Antigen presentation and Vaccine Design.
Antonio ZorzanoSpainBarcelonaIRB Barcelona IRB Barcelona, University of Barcelona, CIBERDEMIdentification of novel modulators of autophagy and impact in complex metabolic diseases.
AngeloDe MilitoSwedenStockholmKaolinska InstitutMC TIdentify the mechanisms mediating the role of autophagy in cancer cells adaptation to acidosis. Identify effective autophagy inhibitors active on cancer cells adapted to acidosis.
Andrea CossarizzaItalyModenaUniversity of Modenaand Reggio EmiliaMC S / TC VLImmunopathogenesis of HIV infection; Immunology of Aging; Immunological alterations in Multiple Sclerosis; role of mitochondria in cell death and survival.
Helga OgmundsdottirIcelandReykjavikUniversity of IcelandMC TInterested in various aspects of the cell biology of breast cancer, including cytogenetics of breast cancer. Also molecular changes in mucosal lesions in the mouth and oral cancer. Furthermore, projects linking the study of immunology and malignancy, studying the genetic and biological basis of B-cell-derived malignancies. In a long-standing collaboration with the Faculty of Pharmaceutical Sciences the effects of lichen-derived compounds on cancer cells have been investigated. Biobank-based research on cancer causes in international collaborations. Finally, a small project on the effect of loss of the thymus during cardiac surgery in infancy on T-cell function.
Regina MenezesPortugalOeirasEstação Agronómica Nacional - Edificio iBET/ITQBMC SInterests focused on translational science mainly (1) the dissection of the molecular mechanisms underlying Islet Amyloid PolyPeptide (IAPP) cytotoxicity in DIABETES MELLITUS – type 1 and 2 as well as pancreas transplantations – and (2) the identification/deep characterization of PROTECTIVE PHYTOCHEMICALS. For that, investing huge efforts in the development of amenable disease models aiming at exploitation of new therapeutic strategies
Bassam JanjiLuxembourgLuxemburgLuxembourg Institut Of HealthMC TInvestigate the role of autophagy in the regulation of the anti-tumor immune response under hypoxic stress.
JosefinaCasas BrugulatSpainBarcelonaCSICLipids. Lipidomics. Design, synthesis and evaluation of inducers/inhibitors of autophagy. Development of high throughput screening methods.
Benjamin DehayFranceBordeauxIMN-CNRS UMR 5293DC LLysosomal Impairment, Parkinson's disease, Therapeutic approaches.
Devrim GozuacikTurkeyTuzlaSabanci UniversityMC TMammalian autophagy basic mechanisms. Autophagy regulating new proteins and pathways microRNA regulation of autophagy. Role of autophagy abnormalities in diseases (cancer, neurodegenerative diseases, stroke). Manipulation of autophagy for disease treatment. Use of nano particles as autophagy drug carriers. Innovative medical device/tool development and autophagy.
Nicolas DeconinckBelgiumGentHôpital Universitaire des Enfants Reine FabiolaMechanisms of autophagy at play in neuromuscular disorders, in particular in COL VI myopathies.
Maria Cristina AlbertiniItalyUrbinoUniversity Of Urbino "Carlo Bo"MicroRNAs involved in the epigenetic regulation of autophagy.
Raquel LimaPortugalPortoIPATIMUP/i3SMC SModulation of autophagy for cancer therapy
Michael ThummGermanyGöttingenGeorg August universität, UniversitatsmedizinMolecular mechanism on autophagy in S.cerevisiae.
Felipe X.Pimentel-MuiñosSpainSalamancaCentro de Investigación del Cáncer. Universidad Salamanca. CSICMolecular mechanisms involved in atypical autophagy against single membrane subcellular structures. Involvement of Atg16L1 in autophagy against infectious agents (xenophagy). Molecular bases of Crohn's disease.
Marja JäätteläDenmarkCopenhagenDanish Cancer SocietyMC TMolecular mechanisms of autophagy, focus on cancer, signalling pathways and lipids.
Carlos GuillénSpainMadridUniversidad Complutense de MadridmTORC1, SIRT1, insulin, amylin, aging, resveratrol, diabetes.
Kenneth A. DawsonIrelandDublinUniversity college DublinNanomaterial interactions with organisms.
Francisco WandosellSpainMadridCSIC Centro Biologiía Molecular Severo OchoaNeurodegeneration, Neuritogenesis , Neuronal morphogenesis, Alzheimer, Ischemia, Neuronal and Glial signalling.
Marta Martínez-VicenteSpainBarcelonaVall d'Hebron Institut de RecercaMC SNeurodegeneration, Parkinson, Huntington, therapy, nanotechnology.
Javier Díaz-NidoSpainMadridUniversidad Autónoma de MadridNeurodegeneration. Mitophagy. Friedreich's ataxia.
Julien PuyalSwitzerlandLausanneUniversity of Lausanne,Department of Fundamental Neurosciences, Puyal- Truttmann LabMC SNeuroprotection ,Cerebral hypoxia-ischemia, excitotoxicity, neuronal death
JuanIovannaFranceMarseilleINSERMTC SAPancreatic cancer.
Maria XilouriGreeceAthensBiomedical Research Foundation of the Academy of AthensMC SPathogenesis of neurodegenerative diseases with an emphasis on the interrelationship between aggregated-prone proteins such as alpha-synuclein, MAPT/tau or beta-amyloid, to lysosomal degradation pathways.
Heinz JungbluthUnited KingdomLondonKIng's College LondonMC SPeadiatry
SophiePattingreFranceMontpellierINSERM Posttranslational modifications of atg proteins and cancer.
Antonio CuadradoSpainMadridUniversidad Autónoma de MadridProteostasis alterations of Alzheimer and Parkinson’s disease and the possibility to use autophagy as a therapeutic target.
Mario ChiarielloItalySienaConsiglio Nazionale Delle RicercheRegulation of autophagy by MAP kinase.
Simone FuldaGermanyFrankfurtGoethe University FrankfurtRegulation of autophagy in cancer, therapeutic targeting of autophagy pathways.
Audrey EsclatineFranceParisUniversité Paris Sud CNRS-I2BCRelationships between autophagy and viral infection.
Dan GrandérSwedenStockholmKaolinska InstitutRole in cancer and in sensitivity/resistance to anti-cancer therapy, screening of all anti-cancer drugs for autophagy induction, non-coding RNA in autophagy, biomarkers for autophagy in patients with cancer, development of novel anti-autophagy therapy.
Patricia BoyaSpainMadridCSCIMC S / SC LRole of autophagy during development and disease, focus on neurons.
Sylvie GiuriatoFranceToulouseINSERM- Cancer Research Center ToulouseRole of autophagy in ALK positive anaplastic large cell lymphoma growth, regression and relapse.
RicardoSánchez-PrietoSpainAlbaceteUniversidad de castilla de la ManchaRole of autophagy in cancer therapy.
Guillermo Velasco DíezSpainMadridMC S / WG4 LRole of autophagy in cancer, sphingolipids, autophagy-mediated cancer cell death, autophagy signalling.
Kevin RyanUnited KingdomGlasgowCancer Research UK Beatson InstitutRole of autophagy in cell death and cancer.
Céline GongoraFranceMontpellierIRCM, Institut de Recherche en Cancérologie de Montpellier; INSERMRole of autophagy in drug resistance in cancer
Annemarie MeijerNetherlandsLeidenLeiden University Institut of BiologieMC TRole of autophagy in host defense against intracellular bacteial infections. Using zebrafish as a model to study autophagy in vivo and recently found that the autophagy modulator dram1 is induced by Toll-like receptor and NFkB mediated signaling and protects the zebrafish host against mycobacterial infection. Using the zebrafish model for screening of autophagy-modulating drugs.
Silvia CarloniItalyUrbinoUniversity Of UrbinoRole of autophagy in neurodegeneration after neonatal brain ischemia.
Fatima Mechta-Grigoriou FranceParisInstitut CurieRole of autophagy in triple-negative breast cancers.
Gabor JuhaszHungaryBudapestEOTVOS Lorand UniversityMC TRoles and molecular mechanisms of autophagy in Drosophila.
Rüta NavakauskienèLithuaniaVilniusVilnius UniversityMC SStudies of molecular mechanisms in normal and cancer cells to determine new possibilities of leukemia differentiation therapy. Identification of proteins that might be involved in signaling events that mediate cancer cell differentiation. Studies of autophagy and apoptosis signaling in cancer and adult stem cell models in vitro.
Veronika BorutinskaiteLithuaniaVilniusVilnius UniversityMC TStudies of molecular mechanisms in normal and cancer cells to determine new possibilities of leukemia differentiation therapy. Identification of proteins that might be involved in signaling events that mediate cancer cell differentiation. Studies of autophagy and apoptosis signaling in cancer and adult stem cell models in vitro.
Thierry ArnouldBelgiumNamurUniversité de Namur / University of NamurMC SStudy of mitochondrial function and dysfunction in stem cell differentiation, metabolism, cancer and bacterial infection
Fulvio Reggiori NetherlandsGroningenUniversity of Groningen, University Medical Center GroningenMC TStudy of the regulation and mechanism of autophagy using yeast as a model system. Study the role of autophagy during viral infections.
Jesús RuberteSpainBarcelonaUniversitat Autònoma de BarcelonaStudy the role of autophagy during aging and disease in retinal blood vessels
Guido KroemerFranceParisINSERMStudying pharmacological, genetic, nutritional or behavioral interventions that induce autophagy and that may have positive effects on normal or pathological aging, as well as several major diseases (cancer, neurodegeneration) and the most frequent "rare" diseases (cystic fibrosis and Wilson disease).
Kathrin PallaufGermanyKielInstitute of Human Nutrition and Food Science (University of Kiel)Studying the impact of potential autophagy-inducing agents (e.g. resveratrol) found in dietary plants on ageing-related processes.
Patrick AubergerFranceNiceINSERMTargeting autophagy in hematopoietic malignancies and deciphering the role of autophagy in hematopoeitic cell differentiation
Beata PajakPolandWarszawaMossakowski Medical Research CentreMC TThe importance of autophagy in neurodegenerative diseases (AD), cancer, as well as metabolic syndrome.
Isabelle VergneFranceToulousePBS-CNRSMC SThe primary objective is to decode the regulation and the role of autophagy in myocbacterial infections, such as Tuberculosis, in order to propose novel vaccines and therapeutics based on autophagy.
Penny LovatUnited KingdomNewcastle Upon TyneNewcastle UniversityMC TTo define and validate novel autophagy biomarkers and drug targets to aid stratified medicine and the development of more efficacious therapeutic strategies to harness autophagy modulation for the clinical benefit of cancer, in particular melanoma and SCC.
Hans-Uwe SimonSwitzerlandBernUniversity of BernTo determine the role of autophagy in the pathogenesis of inflammatory diseases and cancer.
Andrea BallabioItalyPozzuoli TIGEMTo develop tools, to modulate cellular clearance and to use them to cure human diseases, including LSDs and neurodegenerative diseases such as Huntington’s, Alzheimer’s and Parkinson’s.
Hang NguyenFranceClermont-ferrandINSERMTo investigate the role of autophagy in host responses to infection with bacteria associated to Crohn's disease.
Pierre-Emmanuel RautouFranceParisInserm- INSERM U970Translation. Role of autophagy in liver disorders and role of autophagy in endothelial cells.
Sophie LanoneFranceCréteilINSERMUnderstand the pulmonary effects of (manufactured) nanoparticles on autophagy pathway, and the role of autophagy in the biological response to (manufactured) nanoparticles.
Pura Muñoz-CánovesSpainBarcelonaUniversitat Pompeu Fabra Understanding how autophagy is altered in aging and disease using skeletal muscle stem cells as a model system.
Matthew GeggUnited KingdomLondonUniversity College LondonUnderstanding how impairment of autophagy-lysosome pathway contributes to Parkinson's disease pathogenesis.
Tassula Proikas-CezanneGermanyTubingenEberhard Karls University TuebingenMC T / WG2 LWIPI-mediated autophagy in health and disease and High throughput / content assessments and screening approaches.
Francesco CecconiDenmarkCopenhagenKraeftens BekaempelseMC SWorking on the elucidation of the upstream autophagy regulation pathways, focussing on protein post-translational modifications (phosphorylation, sumoylation, ubiquitylation) and autophagy complexes' formation. In cancer, it is testing a set of Ambra1- (or Ambra1 cofactors, such as ULK1, TRAF6, DLC1 or PP2A) interfering small peptides for their ability to regulate autophagy in tumor-model cell lines of the lung, breast and melanoma. Also, it is producing autophagy-related mouse systems to test compunds in vivo.
Henrique GiraoPortugalCoimbraFaculty of Medicine University of Coimbra-IBILIMC TWorking on the molecular mechanisms involved in ubiquitin-dependent autophagy degradation of membrane proteins; cross talk endocytosis - autophagy; autophagy in heart in health and disease; autophagosome biogenesis.
Alexander Pintzas Greece Athens National Hellenic Research FoundationMy research interests have been in the scientific areas of Biology of Cancer and Cell Death, towards exploitation of the interplay of proliferative with apoptotic/autophagic pathways for novel cancer therapeutics and their rational combinations
Giulia Riparini Italy Urbania University of Urbino Carlo BoAutophagy and endoplasmic reticulum stress in neurodegeneration and neuroprotection after perinatal brain damage
Muriel Priault France Bordeaux Centre National de Recherche Scientifique CNRSAutophagy, cancer, trafic, mitochondria, Bcl-xL, Rab7.
EstherDalfó Spain Barcelona Universitat Autònoma de BarcelonaConverging mechanisms between autophagy and axonal
function and the metabolic influence in the regulation of neurodegenerative
diseases
IrenaAudzeyenka Poland Warsaw Polish Academy of Sciences Define the significance of autophagy for podocyte survival and function, as well as to assess the involvement of this process into pathogenesis of diabetic nephropathy.
Ziga JakopinSloveniaLjubljana University of LjubljanaMC TDesign/synthesis of ligands of pattern recognition receptors; Identification and biological evaluation of NOD1/2 receptor (ant)agonists; medicinal chemistry.
Vincent Lotteau France Lyon Centre International de Recherche en InfectiologieDevelopment of host-oriented antiviral molecules.
Ana Vanessa Oliveira Portugal Oeiras Instituto de Biologia Experimental e Tecnológica and Instituto de Tecnologia Química e Biológica (ITQB/UNL) Focused on translational science mainly biochemistry, cellular and molecular biology and its application to the field of gene therapy, development of biopolymers and diabetes. Interested in developing new disease models, including yeast models to complement tests in mammalian cells and animal models involved in the development of new therapeutical strategies.
KarolinaPircs SwedenLund Lund UniversityI am currently working on the linkage of autophagy and miRNAs in different neurodegenerative disorders like Huntington´s disease and Parkinson´s disease.
Ioannis Trougakos GreeceAthens National & Kapodistrian University of AthensMC SMCAC focuses on proteome stability alterations during ageing and in age‐related diseases, as well as in the discovery of natural compounds that reduce proteome aggregation and prolong proteome stability and longevity at either cell‐based and/or at in vivo experimental models.

WG5

Biomedical Translation & Clinical Trials
María Morán

María Morán Leader

Marta Martínez

Marta Martínez Vice-Leader

WG5 translate results into benefits to patients by tackling: i) biomarker discovery; ii) development of strategies to foster healthy aging; and iii) development of therapeutic strategies to treat a variety of diseases.

Secondary objectives include:

  1. Identify needs of basic investigators for models or physiologically relevant systems to validate candidate biomarkers, pathways, or compounds in vivo (human tissue biopsies or fluids).
  2. Identify research partners for clinicians interested in defining mechanistic aspects of observations identified in their clinical practice.
  3. Evaluate the genetics, biochemistry, and cell biology of autophagy in different human diseases.
  4. Foster discussion, identification, and validation of novel autophagy related factors to provide new mechanistic insight into the role of lysosomal-mediated processes in disease.
  5. Support specific translational biomedical research actions to identify new signaling cascades that may be modulated or controlled by autophagy and to determine how these pathways are rewired during pathological situations.
  6. Investigate and develop novel strategies through which to exploit and harness autophagy for the prevention and/or diagnosis of diseases of interest of members of the COST Action (e.g., vaccines, immune activation, exercise, drug treatment).
  7. Serve as a forum for discussion among members of the WG regarding therapeutic approaches already available (exercise, drug treatment, nutritional care, among others) to limit or avoid muscle wasting in different human conditions (e.g., cancer, aging, neuromuscular disorders).
  8. Lead meta-analysis regarding modulation of autophagy as therapeutic approach in human diseases.

The activities to be carried out will include the generation of a database of clinical researchers working with human clinical samples (tissue biopsies, serum, plasma, urine or bucal swaps, among others), who are interested in collaborative functional or validation studies using their clinical samples. This database will be accessible to all partners in this Action. The Action expects that members of the other Working Groups, especially basic researchers and biotechnological company scientist, will particularly benefit as it is often difficult to find suitable clinical partners. Therefore, the Action anticipates numerous and productive synergies in different human pathologies.

 Name SurnamesCountryCityInstitutionCharge Research Line
Alejandro LuciaSpainMadridLaureate - Universidad EuropeaImproved autophagy as a main biological mechanism mediating the health benefits of physical exercise.
Arnaud MorisFranceParisCenter for Immunology and Microbial infections - ParisHost-Pathogen interactions, Adaptive Immunity, Inflammation, Antigen presentation and Vaccine Design.
Aurelio Hernández LaínSpainMadridHospital Universitario 12 de OctubreClinical trials for patients with cerebral tumors.
BeataSikorska Poland Lodz Medical University of LodzOur group is working on autophagy in prion  diseases and neurodegeneration in humans
Benjamin DehayFranceBordeauxIMN-CNRS UMR 5293DC LLysosomal Impairment, Parkinson's disease, Therapeutic approaches.
Cecilia Marelli France Montpellier CHRU Gui de Chauliac Aggregation-directed peptide therapy for Huntington's disease; stimulation of autophagy to eliminate free polyQ huntingtin protein
Christophe BautersFranceLille CedexUniversité Lille Nord de FranceTranslational research in heart failure.
Dan GrandérSwedenStockholmKaolinska InstitutRole in cancer and in sensitivity/resistance to anti-cancer therapy, screening of all anti-cancer drugs for autophagy induction, non-coding RNA in autophagy, biomarkers for autophagy in patients with cancer, development of novel anti-autophagy therapy.
Daria Ler Bosnia and Herzegovina Sarajevo PZU "Moja Klinika" MC TIdentifying risk markers and elucidating pathways responsible for breast cancer cell proliferation is important for the improvement of the risk classification in patients as well as discovery of therapeutic targets. Currently, MACC1 protein expression studies in clinical-pathologically characterized breast cancer samples was evaluated only by immunohistochemistry and showed significant MACC1 expression associated with clinical stage and lymph node metastasis. We aimed to investigate potential role of MACC1 as an effective therapeutic target and to elucidate the possible role of MACC1 in breast cancer metastasis. Taken together, MACC1 harbors a great potential to be used in clinics as a prognostic marker for the identification of high-risk patients and could be used to predict cancer recurrence and therapy response.
Delia GolettiItalyRomaNational institut for Infectious Diseases "Lazzaro Spallanzani" impact of autophagy on M. tuberculosis.
DiegoTosiFranceMontpellierICMImplementation of early clinical trials in cancer patients.
Enzo EmanueleItalyRobbio2 E SCIENCEI work on the application of autophagy in skincare products, as well as on autophagy markers in longeve individuals.
Fabio PennaItalyTorinoUniversity of TorinoCancer cachexia, skeletal muscle, wasting, hypercabolism, mitochondria.
Francesco CecconiDenmarkCopenhagenKraeftens BekaempelseMC SWorking on the elucidation of the upstream autophagy regulation pathways, focussing on protein post-translational modifications (phosphorylation, sumoylation, ubiquitylation) and autophagy complexes' formation. In cancer, it is testing a set of Ambra1- (or Ambra1 cofactors, such as ULK1, TRAF6, DLC1 or PP2A) interfering small peptides for their ability to regulate autophagy in tumor-model cell lines of the lung, breast and melanoma. Also, it is producing autophagy-related mouse systems to test compunds in vivo.
Guillermo Velasco DíezSpainMadridUniversidad Computense de MadridMC S / WG4 LRole of autophagy in cancer, sphingolipids, autophagy-mediated cancer cell death, autophagy signalling.
Heinz JungbluthUnited KingdomLondonKIng's College LondonMC SPeadiatry
Ioannis TrougakosGreeceAthensNational & Kapodistrian University of Athens,MC SMCAC focuses on proteome stability alterations during ageing and in age‐related diseases, as well as in the discovery of natural compounds that reduce proteome aggregation and prolong proteome stability and longevity at either cell‐based and/or at in vivo experimental models.
Jessica MartinssonSwedenHuddingeSprint BioscienceIdentifying autophagy inhibitors targeting Vps34 as cancer treatment. Program currently in lead optimization after a successful proof-of-principle study in vivo.
Jordi Alcaraz Spain Barcelona Universitat de BarcelonaStudying the role of tumor associated fibroblasts (TAFS) in lung cancer progression
José A. Sánchez AlcázarSpainSevillaUniversidad Pablo de OlavideMitophagy
JuanSepúlveda SánchezSpainMadridHospital Universitario 12 de OctubreClinical trials for patients with cerebral tumors.
Juan A. G.RaneaSpainMálagaUniversidad de MálagaBioinformatics and biology network associations.
Maria XilouriGreeceAthensBiomedical Research Foundation of the Academy of AthensMC SPathogenesis of neurodegenerative diseases with an emphasis on the interrelationship between aggregated-prone proteins such as alpha-synuclein, MAPT/tau or beta-amyloid, to lysosomal degradation pathways.
Maria Cristina AlbertiniItalyUrbinoUniversity Of Urbino "Carlo Bo"MicroRNAs involved in the epigenetic regulation of autophagy.
Mario P.TschanSwitzerlandBernUniversity of BernMC TCell Differentiation, physiology an dynamics.
Marta Martínez-VicenteSpainBarcelonaVall d'Hebron Institut de RecercaMC SNeurodegeneration, Parkinson, Huntington, therapy, nanotechnology.
María SoengasSpainMadridSpanish National Research CentreWG5 SAMolecular basis of melanoma progression and response to therapy.
María MoránSpainMadridInstituto de investigación Hospital 12 de OctubreMC T / WG5 LMitochondrial diseases, autophagy modulation, therapy, muscle wasting, neurodegeneration.
Maurizio MuscaritoliItalyRomaSapienza Università di RomaRole of autophagy in muscle wasting.
Miguel Ángel MartínSpainMadridServicio Madrileño de la salud. Hospital 12 de OctubreDiagnosis and physiopathology of mitochodrial diseases and other neuromuscular disorders, the role of autopahagy in these diseases.
Mirza Suljagic Bosnia and Herzegovina Sarajevo International University of SarajevoMC TWe are studying  apoptosis and autophagy  regulatory proteins in Chronic myelogenous leukemia (TKI sensitive vs. TKI resistant) and Diffuse large B cell lymphoma (GC vs. ABC origin). We are targeting selected regulatory pathways with our candidate compounds  for improving current treatment options.
Mojgan Djavaheri-MergnyFranceBordeauxINSERM- INSERM U916Deciphering the role of autophagy in cancer cells.
Patrice CodognoFranceParisINSERMMC T / Vice ChairMembrane dynamics of autophagosomal compartment. Interplay between autophagy and the primary cilium: role in mechanical stress integration. Role of autophagy in self-renewal of cancer stem cells and their targeting in breast cancer treatment.
Paul HofmanFranceNiceInstitut for Recherch on Cancer and Aging, Nice (INSERM)Tumor Bank
Paulina Langa Poland Gdansk Medical University of Gdansk"My primary research interests are mostly in the area of stem cells and transla onal medicine. I
am currently op mising a protocol for transplan ng in vitro cultured epidermal cells in the
treatment of chronic wounds a7er burns and diabe c ulcers."
Penny LovatUnited KingdomNewcastle Upon TyneNewcastle UniversityMC TTo define and validate novel autophagy biomarkers and drug targets to aid stratified medicine and the development of more efficacious therapeutic strategies to harness autophagy modulation for the clinical benefit of cancer, in particular melanoma and SCC.
Raphaël RodriguezFranceParisInstitut CurieIdentify small molecule regulators of autophagy.
Ricardo PereiraPortugalCoimbraCentro Hospitalar e Universitario de Coimbra
Rui BaptistaPortugalCoimbraFaculty Of Medicine University of CoimbreTranslational projects that intend to investigate the role of autophagy in the maintenance of protein homeostasis in the heart.
Silvia CarloniItalyUrbinoUniversity Of UrbinoRole of autophagy in neurodegeneration after neonatal brain ischemia.
Stéphane NanceyFranceInflammatory bowel diseases, especially in dissecting the immunologic mechanisms by which gut inflamation and lesions occurred using animal models of colitis and research in humans.
Sylviane MullerFranceStrasbourgCNRSTC SAAutoimmunity, systemic autoimmune diseases, lupus. T cell and B cell epitopes, antigen-presenting cells, antibody-secreting cells, cytokines. Immunomodulation, altered peptide ligand of the T cell receptor. Autophagy, CMA, MIIC compartment, pharmacological regulators of autophagy, lysosomes. Therapeutic stratégies, mouse models of autoimmunity, autoantibodies to "some" structures. Patients, clinical trials.
TeresaSardonSpainBarcelonaAnaxomics Biotech
Walter Balduini Italy Urbino University Of Urbin "Carlo Bo"MC T / TC LRole of autophagy in neurodegeneration after toxic insult during brain development.
Ömer Nuri PamukTurkeyEdirneTrakya UniversityMC T

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